Evidence map›Paper›PMID 28601429›Full record

ReviewVision research2017

OCT angiography and visible-light OCT in diabetic retinopathy.

Peter L Nesper, Brian T Soetikno, Hao F Zhang, Amani A Fawzi

Abstract readReview
In one paragraph

Review in Vision research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Diabetic macular ischaemia- a new therapeutic target?Progress in retinal and eye research · 2022
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Artifacts and artifact removal in optical coherence tomographic angiography.Quantitative imaging in medicine and surgery · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter L NesperDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA. Electronic address: nesperpl@gmail.com.
Brian T SoetiknoDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. Electronic address: briansoetikno@gmail.com.
Hao F ZhangDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. Electronic address: hfzhang@northwestern.edu.
Amani A FawziDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA. Electronic address: afawzimd@gmail.com.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Investigating oxygen metabolism in diabetic retinopathyR01EY026078 · NEI · NORTHWESTERN UNIVERSITY · PI SHEIBANI, NADER, ZHANG, HAO F · 2016 to 2020
$2.3M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
Oxygen delivery and metabolism in diabetic retinopathy using visible-light optical coherence tomographyF30EY026472 · NEI · NORTHWESTERN UNIVERSITY · PI SOETIKNO, BRIAN THEODORE · 2016 to 2020
$193k
NEI NIH HHS F30 EY026472NEI NIH HHS R01 EY026078NIDDK NIH HHS DP3 DK108248NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

In recent years, advances in optical coherence tomography (OCT) techniques have increased our understanding of diabetic retinopathy, an important microvascular complication of diabetes. OCT angiography is a non-invasive method that visualizes the retinal vasculature by detecting motion contrast from flowing blood. Visible-light OCT shows promise as a novel technique for quantifying retinal hypoxia by measuring the retinal oxygen delivery and metabolic rates. In this article, we discuss recent insights provided by these techniques into the vascular pathophysiology of diabetic retinopathy. The next milestones for these modalities are large multicenter studies to establish consensus on the most reliable and consistent outcome parameters to study diabetic retinopathy.

Indexed as

Computed Tomography AngiographyDiabetic RetinopathyHumansImaging, Three-DimensionalRetinal VesselsTomography, Optical CoherenceDiabetic retinopathyImagingOCTOCT angiographyRetinaVisible-light OCT

Identifiers

PMID28601429
PMCPMC5723235

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.