Evidence map›Paper›PMID 28601302›Full record

ArticleThe Journal of surgical research2017

Traumatic brain injury impairs sensorimotor function in mice.

Adrian M Sackheim, David Stockwell, Nuria Villalba, Laurel Haines, Chary L Scott, Sheila Russell, Sayamwong E Hammack, Kalev Freeman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. Review
  6. Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Adrian M SackheimDepartment of Surgery, University of Vermont, Burlington, Vermont.
David StockwellDepartment of Surgery, University of Vermont, Burlington, Vermont.
Nuria VillalbaDepartment of Surgery, University of Vermont, Burlington, Vermont; Department of Pharmacology, University of Vermont, Burlington, Vermont.
Laurel HainesDepartment of Surgery, University of Vermont, Burlington, Vermont.
Chary L ScottDepartment of Pharmacology, University of Vermont, Burlington, Vermont.
Sheila RussellDepartment of Surgery, University of Vermont, Burlington, Vermont.
Sayamwong E HammackDepartment of Psychological Science, University of Vermont, Burlington, Vermont.
Kalev FreemanDepartment of Surgery, University of Vermont, Burlington, Vermont; Department of Pharmacology, University of Vermont, Burlington, Vermont. Electronic address: Kalev.freeman@uvm.edu.
University of Vermont · US

Funding

Analysis and Characterization of Trauma-Induced CoagulopathyUM1HL120877 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MORRISSEY, JAMES H., WISNIEWSKI, STEPHEN R · 2013 to 2019
$26.6M
Endothelial Ca2+ signals and vasodilatory function after traumatic brain injuryK08GM098795 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FREEMAN, KALEV · 2011 to 2015
$567k
NHLBI NIH HHS UM1 HL120877NIGMS NIH HHS K08 GM098795
6 · The paper itself

Abstract

introductionUnderstanding the extent to which murine models of traumatic brain injury (TBI) replicate clinically relevant neurologic outcomes is critical for mechanistic and therapeutic studies. We determined sensorimotor outcomes in a mouse model of TBI and validated the use of a standardized neurologic examination scoring system to quantify the extent of injury. MATERIALS AND

methodsWe used a lateral fluid percussion injury model of TBI and compared TBI animals to those that underwent sham surgery. We measured neurobehavioral deficits using a standardized 12-point neurologic examination, magnetic resonance imaging, a rotating rod test, and longitudinal acoustic startle testing.

resultsTBI animals had a significantly decreased ability to balance on a rotating rod and a marked reduction in the amplitude of acoustic startle response. The neurologic examination had a high inter-rater reliability (87% agreement) and correlated with latency to fall on a rotating rod (R

conclusionsTBI impairs sensorimotor function in mice, and the extent of impairment can be predicted by a standardized neurologic examination.

Indexed as

AnimalsBrain Injuries, TraumaticInjury Severity ScoreMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLNeurologic ExaminationNeuropsychological TestsObserver VariationPostural BalanceRandom AllocationReflex, StartleAcoustic startle responseInjury severity scoreNeurologic assessmentSensorimotor functionTraumatic brain injury

Identifiers

PMID28601302
PMCPMC5996987
OpenAlexW2590889653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.