Evidence map›Paper›PMID 28601095›Full record

ArticleJournal of neuroengineering and rehabilitation2017

Reactive stepping with functional neuromuscular stimulation in response to forward-directed perturbations.

Alexander J Hunt, Brooke M Odle, Lisa M Lombardo, Musa L Audu, Ronald J Triolo

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Feasibility of a Center of Mass Based Fuzzy-Logic Phase Detection Algorithm for Post-Spinal Cord Injury Gait.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alexander J HuntDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA. ajh26@pdx.edu.
Brooke M OdleDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Lisa M LombardoDepartment of Veterans Affairs, Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, 44106, USA.
Musa L AuduDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ronald J TrioloDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USPortland State University · US

Funding

Automatic Control of Standing Balance with Functional Neuromuscular StimulationR01NS040547 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI AUDU, MUSA L, TRIOLO, RONALD J · 2000 to 2022
$7.2M
NINDS NIH HHS R01 NS040547
6 · The paper itself

Abstract

backgroundImplanted motor system neuroprostheses can be effective at increasing personal mobility of persons paralyzed by spinal cord injuries. However, currently available neural stimulation systems for standing employ patterns of constant activation and are unreactive to changing postural demands.

methodsIn this work, we developed a closed-loop controller for detecting forward-directed body disturbances and initiating a stabilizing step in a person with spinal cord injury. Forward-directed pulls at the waist were detected with three body-mounted triaxial accelerometers. A finite state machine was designed and tested to trigger a postural response and apply stimulation to appropriate muscles so as to produce a protective step when the simplified jerk signal exceeded predetermined thresholds.

resultsThe controller effectively initiated steps for all perturbations with magnitude between 10 and 17.5 s body weight, and initiated a postural response with occasional steps at 5% body weight. For perturbations at 15 and 17.5% body weight, the dynamic responses of the subject exhibited very similar component time periods when compared with able-bodied subjects undergoing similar postural perturbations. Additionally, the reactive step occurred faster for stronger perturbations than for weaker ones (p < .005, unequal varience t-test.)

conclusionsThis research marks progress towards a controller which can improve the safety and independence of persons with spinal cord injury using implanted neuroprostheses for standing.

Indexed as

Electric StimulationNeural ProsthesesWalkingAccelerometryAlgorithmsBiomechanical PhenomenaElectrodes, ImplantedHumansMaleMiddle AgedMuscle, SkeletalParaplegiaPhysical Therapy ModalitiesPostural BalanceSpinal Cord InjuriesFunctional neuromuscular stimulationNeuroprosthesesReactive steppingSpinal cord injuryStanding balance

Identifiers

PMID28601095
PMCPMC5466798
OpenAlexW2621639827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.