ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2017
Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection.
Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06578871 (Surgery for the Unknown Primary in the Era of p16-positive Oropharyngeal Squamous Cell Carcinoma), which is not on this map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surgery for the Unknown Primary in the Era of p16-positive Oropharyngeal Squamous Cell Carcinoma: Reducing Ionizing Radiation (SUPERIOR): A Randomized Trial
Who cites it
22 citing papers in PubMed.
- Comparable Outcomes Without Routine Pan-mucosal Irradiation in Head and Neck Carcinoma of Unknown Primary.Advances in radiation oncology · 2026Article
- Head and neck cancer of unknown primary: a nationwide analysis of hospital-based cancer registry data in Japan, 2018-2022.International journal of clinical oncology · 2026Review
- Review
- Impact of implementing stricter criteria for blood transfusion in patients with head and neck cancer undergoing free tissue transfer.Laryngoscope investigative otolaryngology · 2024Article
- Head and Neck Cancer of Unknown Primary: A Multicenter Retrospective Cohort study in Northern Thailand, an Endemic Nasopharyngeal Cancer Area.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- A comparison between p16-positive head and neck cancer of unknown primary (HPV-HNCUP) and oropharyngeal squamous cell carcinoma (HPV-OPSCC): are they the same disease?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Survival Outcome in True Carcinoma of Unknown Primary (tCUP) with p16 + Cervical Metastasis.International archives of otorhinolaryngology · 2023Article
- Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea.Journal of pathology and translational medicine · 2023Article
- Understanding the Role of Human Papillomavirus in Head and Neck Cancer of Unknown Primary: A Systematic Review.Cureus · 2023Review
- Factors Influencing the Outcome of Head and Neck Cancer of Unknown Primary (HNCUP).Journal of clinical medicine · 2022Article
- Prospective Evaluation of Swallowing Symptoms in Human Papillomavirus-Associated Oropharynx Cancer.Dysphagia · 2022Article
- Article
- Review
- Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival.International archives of otorhinolaryngology · 2021Article
- Impact of Neck Dissection in Head and Neck Squamous Cell Carcinomas of Unknown Primary.Cancers · 2021Article
- Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life.International journal of particle therapy · 2021Article
- Approach to the Patient with Unknown Primary Squamous Cell Carcinoma of the Head and Neck.Current treatment options in oncology · 2020Review
- Significance of the Neutrophil-to-Lymphocyte Ratio in p16-Negative Squamous Cell Carcinoma of Unknown Primary in Head and Neck.Frontiers in oncology · 2020Article
- PD-1 and PD-L1 Expression Predicts Radiosensitivity and Clinical Outcomes in Head and Neck Cancer and is Associated with HPV Infection.Journal of Cancer · 2019Article
- HPV Could be a Potential Factor of Survival in Laryngeal Cancer: a Preliminary Study in Mexican PatientsAsian Pacific journal of cancer prevention : APJCP · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHead and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is not yet established, and the reported survival rates vary. In the last decade, human papilloma virus (HPV) has been identified as a common cause of and important prognostic factor in oropharyngeal cancer, and there is now growing interest in the importance of HPV for HNCUP. The aim of the present study on curatively treated HNCUP was to investigate the prognostic importance of different factors, including HPV status, treatment, and overall survival.
methodsA search for HNCUP was performed in the Swedish Cancer Registry, Western health district, between the years 1992-2009. The medical records were reviewed, and only patients with squamous cell carcinoma or undifferentiated carcinoma treated with curative intent were included. The tumor specimens were retrospectively analyzed for HPV with p16 immunostaining.
resultsSixty-eight patients were included. The mean age was 59 years. The majority were males, and had N2 tumors. Sixty-nine percent of the tumors were HPV positive using p16 staining. Patients who were older than 70 years, patients with N3-stage tumors, and patients with tumors that were p16 negative had a significantly worse prognosis. The overall 5-year survival rate for patients with p16-positive tumors was 88% vs 61% for p16-negative tumors. Treatment with neck dissection and postoperative radiation or (chemo) radiation had 81 and 88% 5-year survival rates, respectively. The overall and disease-free 5-year survival rates for all patients in the study were 82 and 74%.
conclusionsCuratively treated HNCUP had good survival. HPV infection was common. Independent prognostic factors for survival were age over 70 years, HPV status and N3 stage. We recommend that HPV analysis should be performed routinely for HNCUP. Treatment with neck dissection and postoperative radiation or (chemo) radiation showed similar survival rates.
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