ArticleAddiction (Abingdon, England)2017
Examination of cumulative effects of early adolescent depression on cannabis and alcohol use disorder in late adolescence in a community-based cohort.
Article in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Substance use and co-occurring mental health conditions among adolescents and young adults in North America: a systematic review.BMC psychiatry · 2026Pooled it
- Examining bidirectional associations between cannabis use and internalizing symptoms among high-risk emerging adults: A prospective cohort study.Psychological medicine · 2025Article
- Mood instability as a transdiagnostic predictor of cannabis use in attention-deficit/hyperactivity disorder and depression: A natural language processing analysis of electronic health records from 13,025 adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The Longitudinal Association of Cumulative Depression With Cannabis Use Disorder Among Young Adults.Journal of studies on alcohol and drugs · 2025Article
- The Moderating Role of Health Status on the Association Between Depressive Symptoms and Cannabis Vaping.Cannabis (Albuquerque, N.M.) · 2024Article
- Adolescent-onset cannabis use and parenting young children: an investigation of differential effectiveness of a digital parenting intervention.Frontiers in child and adolescent psychiatry · 2024Article
- Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences.Addiction (Abingdon, England) · 2023Article
- Associations between early childhood adversity and behavioral, substance use, and academic outcomes in childhood through adolescence in a U.S. longitudinal cohort.Drug and alcohol dependence · 2023Article
- Assessing cross-lagged associations between depression, anxiety, and binge drinking in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.Drug and alcohol dependence · 2023Article
- Marginal Structural Models for Life-Course Theories and Social Epidemiology: Definitions, Sources of Bias, and Simulated Illustrations.American journal of epidemiology · 2022Article
- Early life mental health and problematic drinking in mid-adulthood: evidence from two British birth cohorts.Social psychiatry and psychiatric epidemiology · 2021Article
- Displayed Depression Symptoms on Facebook at Two Time Points: Content Analysis.JMIR formative research · 2021Article
- Factors associated with health-related cannabis use intentions among a community sample of people who inject drugs in Los Angeles and San Francisco, CA 2016 to 2018.Drug and alcohol dependence · 2021Article
- Down and High: Reflections Regarding Depression and Cannabis.Frontiers in psychiatry · 2021Review
- Cannabis and Depression.Advances in experimental medicine and biology · 2021Review
- Associations between Recent and Cumulative Cannabis Use and Internalizing Problems in Boys from Adolescence to Young Adulthood.Journal of abnormal child psychology · 2020Article
- Management of Complex Co-occurring Psychiatric Disorders and High-Risk Behaviors in Adolescence.Focus (American Psychiatric Publishing) · 2020Article
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- Bidirectional Links Between Maternal and Adolescent Depression: Separating Between and Within Dyad Differences.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsAlthough they often co-occur, the longitudinal relationship between depression and substance use disorders during adolescence remains unclear. This study estimated the effects of cumulative depression during early adolescence (ages 13-15 years) on the likelihood of cannabis use disorder (CUD) and alcohol use disorder (AUD) at age 18.
designProspective cohort study of youth assessed at least annually between 6th and 9th grades (~ age 12-15) and again at age 18. Marginal structural models based on a counterfactual framework that accounted for both potential fixed and time-varying confounders were used to estimate cumulative effects of depressive symptoms over early adolescence.
settingThe sample originated from four public middle schools in Seattle, Washington, USA.
participantsThe sample consisted of 521 youth (48.4% female; 44.5% were non-Hispanic White). MEASUREMENTS: Structured in-person interviews with youth and their parents were conducted to assess diagnostic symptom counts of depression during early adolescence; diagnoses of CUD and AUD at age 18 was based the Voice-Diagnostic Interview Schedule for Children. Cumulative depression was defined as the sum of depression symptom counts from grades 7-9.
findingsThe past-year prevalence of cannabis and alcohol use disorder at the age 18 study wave was 20.9 and 19.8%, respectively. A 1 standard deviation increase in cumulative depression during early adolescence was associated with a 50% higher likelihood of CUD [prevalence ratio (PR) = 1.50; 95% confidence interval (CI) = 1.07, 2.10]. Although similar in direction, there was no statistically significant association between depression and AUD (PR = 1.41; 95% CI = 0.94, 2.11). Further, there were no differences in associations according to gender.
conclusionsYouth with more chronic or severe forms of depression during early adolescence may be at elevated risk for developing cannabis use disorder compared with otherwise similar youth who experience fewer depressive symptoms during early adolescence.
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Registered trials
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