Evidence map›Paper›PMID 28600891›Full record

ArticleAllergy2017

Spontaneous food allergy in Was

W S Lexmond, J A Goettel, B F Sallis, K McCann, E H H M Rings, E Jensen-Jarolim, S Nurko, S B Snapper, E Fiebiger

Open access · greenAbstract read
In one paragraph

Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Italian pediatric experts' consensus statement on diagnosis and management of primary atopic disorders.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Guideline
  2. The genetics of hyper IgE syndromes.Frontiers in immunology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Enterocytes in Food Hypersensitivity Reactions.Animals : an open access journal from MDPI · 2021
    Article
  8. Review
  9. The Genetics of Food Allergy.Current allergy and asthma reports · 2018
    Review
  10. Experimental Models for Studying Food Allergy.Cellular and molecular gastroenterology and hepatology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

W S LexmondDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
J A GoettelDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
B F SallisDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
K McCannDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
E H H M RingsDepartments of Pediatrics, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands.
E Jensen-JarolimCenter of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-4019-5765
S NurkoDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
S B SnapperDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
E FiebigerDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3385-0100
Boston Children's Hospital · USLeiden University Medical Center · NLUniversity of Veterinary Medicine Vienna · AT

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Studies of Fc-epsilon-RI as an antigen presentation structure at mucosal surfacesR01AI075037 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI FIEBIGER, ELISABETH EDDA · 2009 to 2013
$2.0M
NIAID NIH HHS R01 AI075037NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

backgroundFood allergies are a growing health problem, and the development of therapies that prevent disease onset is limited by the lack of adjuvant-free experimental animal models. We compared allergic sensitization in patients with food allergy or Wiskott-Aldrich syndrome (WAS) and defined whether spontaneous disease in Was

methodsComparative ImmunoCAP ISAC microarray was performed in patients with food allergy or WAS. Spontaneous food allergy in Was

resultsPolysensitization to food was detected in both WAS and food-allergic patients which was recapitulated in the Was

conclusionsWas

Indexed as

AdultAllergensAnaphylaxisAnimalsDisease Models, AnimalFemaleFood HypersensitivityGene ExpressionHumansImmunizationImmunoglobulin EMaleMast CellsMiceMice, KnockoutPhenotypeAllergensImmunoglobulin EReceptors, IgEWas protein, mouseWiskott-Aldrich Syndrome Proteinadjuvant-free polysensitizationfood allergyhigh-affinity IgE Fc receptormast cellsWiskott-Aldrich syndrome protein

Identifiers

PMID28600891
PMCPMC5698178
OpenAlexW2623840393

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.