Observational studyThe Laryngoscope2018
What drives productivity loss in chronic rhinosinusitis? A SNOT-22 subdomain analysis.
Observational study in The Laryngoscope, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Effect of low salicylate diet on clinical and inflammatory markers in patients with aspirin exacerbated respiratory disease - a randomized crossover trial.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021Trial
- Long-Term Postoperative Patient-Reported Quality of Life After Endoscopic Surgery for Sinonasal Inverted Papilloma: A Longitudinal Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Long-Term Cost Utility Analysis of Endoscopic Sinus Surgery: Analysis of 5-Year Outcomes.The Laryngoscope · 2026Article
- A cost utility analysis for the management of acute exacerbations of chronic rhinosinusitis.International forum of allergy & rhinology · 2025Article
- Patient perspectives on international multidisciplinary consensus criteria for chronic rhinosinusitis disease control.Laryngoscope investigative otolaryngology · 2024Article
- Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis.Allergy · 2024Article
- Revision surgery versus biologic treatment with omalizumab in recurrent chronic rhinosinusitis with nasal polyps: An analysis of cost-utility and clinical outcomes.The World Allergy Organization journal · 2023Article
- Work productivity and activity impairment in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery-A prospective, multi-institutional study.International forum of allergy & rhinology · 2023Observational
- Cost-Utility Analysis of Dupilumab for the Treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in Italy.Journal of personalized medicine · 2022Article
- Biologics for severe uncontrolled chronic rhinosinusitis with nasal polyps: a change management approach. Consensus of the Joint Committee of Italian Society of Otorhinolaryngology on biologics in rhinology.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Review
- Profiling Disease and Economic Burden in CRSwNP Using Machine Learning.Journal of asthma and allergy · 2022Article
- Measurement of some serum cytokines in nasal polyp and evaluation of its correlation with disease severity.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Effect of Functional Endoscopic Sinus Surgery on Outcomes in Chronic Rhinosinusitis.Current allergy and asthma reports · 2020Review
- Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.The journal of allergy and clinical immunology. In practice · 2020Review
- Evolving Rhinology: Understanding the Burden of Chronic Rhinosinusitis Today, Tomorrow, and Beyond.Current allergy and asthma reports · 2020Review
- Socioeconomic status impacts postoperative productivity loss and health utility changes in refractory chronic rhinosinusitis.International forum of allergy & rhinology · 2019Article
- Workplace Indirect Cost Impacts of Nasal and Sinus Symptoms and Related Conditions.Journal of occupational and environmental medicine · 2019Article
- Does Medical Therapy Improve SinoNasal Outcomes Test-22 Domain Scores? An Analysis of Clinically Important Differences.The Laryngoscope · 2019Observational
- Automated classification of osteomeatal complex inflammation on computed tomography using convolutional neural networks.International forum of allergy & rhinology · 2019Article
- Chronic rhinosinusitis control from the patient and physician perspectives.Laryngoscope investigative otolaryngology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectives/hypothesisPrevious studies have shown declines in productivity due to chronic rhinosinusitis (CRS) are correlated with disease-specific quality-of-life (QOL) measures. However, it is unclear which symptom domains contribute primarily to productivity loss. This investigation sought to assess the association between CRS-specific QOL subdomain impairment and productivity loss. STUDY
designProspective, multi-institutional, observational cohort study.
methodsThere were 198 patients with refractory CRS enrolled between August 2012 and June 2015. Baseline QOL measures were obtained across five subdomains of the 22-item SinoNasal Outcome Test (SNOT-22). Lost productivity time was determined from patient-reported measures of annual absenteeism, presenteeism, and lost leisure time, and then monetized using annual daily wage rates from the 2012 US National Census and 2013 Department of Labor statistics.
resultsProductivity losses correlated with impairments in both SNOT-22 psychological dysfunction (Spearman correlation coefficient [Rs] = 0.428, P < .001), and sleep dysfunction domain scores (Rs = 0.355, P < .001). Higher SNOT-22 total scores also significantly correlated with increased monetized productivity losses (Rs = 0.366, P < .001). The mean annual productivity cost was $11,820/patient, whereas patients with comorbid immunodeficiency ($23,285/patient), tobacco use ($23,195/patient), and steroid dependency ($18,910/patient) reported higher than average annual productivity costs. Multivariate linear regression found maximum annual productivity costs in adjusted psychological ($13,300/patient, P < .001) and sleep dysfunction ($9,275/patient, P < .001) domains.
conclusionsImpairments in sleep and psychological SNOT-22 domains correlate with productivity losses. Patients with comorbid immunodeficiency, smoking, and steroid dependency had higher than average productivity losses. Targeted management of psychological and sleep dysfunction in combination with standard symptom control may improve patient-centered care and reduce the annual economic burden of CRS. LEVEL OF EVIDENCE: 2c. Laryngoscope, 128:23-30, 2018.
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