Evidence map›Paper›PMID 28600631›Full record

Observational studyEuropean journal of pediatrics2017

Acute pain management: acetaminophen and ibuprofen are often under-dosed.

Gregorio P Milani, Franca Benini, Laura Dell'Era, Davide Silvagni, Alberto F Podestà, Rossella Letizia Mancusi, Emilio F Fossali, PIERRE GROUP STUDY

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gregorio P MilaniPediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. milani.gregoriop@gmail.com.
Franca BeniniPediatric Pain and Palliative Care Service, Department of Women's and Children's Health, University Hospital, Padua, Italy.
Laura Dell'EraPediatric Emergency Department, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda 9, 20122, Milan, Italy.
Davide SilvagniAzienda Ospedaliera Universitaria Integrata, Verona, Italy.
Alberto F PodestàDipartimento Materno Infantile, ASST Santi Paolo e Carlo, Ospedale San Carlo Borromeo, Milan, Italy.
Rossella Letizia MancusiCREA Sanità, University of Tor Vergata, Rome, Italy.
Emilio F FossaliPediatric Emergency Department, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda 9, 20122, Milan, Italy.
PIERRE GROUP STUDY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most children with pain are managed by either acetaminophen or ibuprofen. However, no study has so far investigated if children are prescribed adequate doses of acetaminophen or ibuprofen in emergency department. Aim of this retrospective study was to investigate the prevalence of under-dosage of these drugs in children presenting with pain in emergency department. Children initially prescribed with acetaminophen or ibuprofen for pain management were included. The χ

conclusionPrescription of acetaminophen and ibuprofen was frequently under-dosed. The use of suppositories, lower and higher body weight, and the use of ibuprofen were associated with under-dosage. Under-dosing may reflect prescription of anti-pyretic doses. CLINICAL

trial registrationAgenzia Italiana del Farmaco-Observational Study Register (RSO). Registration code: PIERRE/1 What is Known: • Pain is frequent in children presented to emergency department. • International recommendations on pain management are often not implemented. What is New: • Acetaminophen and ibuprofen were frequently underdosed in children prescribed for pain in the Italian emergency departments. • Under-dosage may be related to the habit of using acetaminophen and ibuprofen in the recommended range for fever treatment.

Indexed as

AcetaminophenAcute PainAdministration, IntravenousAdministration, OralAdministration, RectalAdolescentAnalgesics, Non-NarcoticChildChild, PreschoolDose-Response Relationship, DrugDrug Dosage CalculationsEmergency Service, HospitalFemaleGuideline AdherenceHealth Care SurveysHumansAcetaminophenAnalgesics, Non-NarcoticIbuprofenBarriersDose errorsFeverOligoanalgesiaPain treatmentParacetamol

Identifiers

PMID28600631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.