ArticleScientific reports2017
Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- From Susceptibility to Disease Severity: Re-Discovering the Clinical Role ofLife (Basel, Switzerland) · 2026Article
- Antimicrobial and immunomodulatory activity of natural bioactive compounds - anFrontiers in immunology · 2025Article
- Association between single nucleotide polymorphisms of interleukin-35 genes and atopic dermatitis.Postepy dermatologii i alergologii · 2024Article
- Article
- Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.PeerJ · 2023Article
- Genetic variants in miR-145 gene are associated with the risk of asthma in Taiwan.Scientific reports · 2022Article
- Association of interleukin-12B rs6887695 with susceptibility to allergic rhinitis.Immunologic research · 2021Article
- Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Interleukin-18 promoter genotype is associated with the risk of nasopharyngeal carcinoma in Taiwan.Cancer management and research · 2018Article
- The rs568408 variant in the IL-12A gene is associated with risk for COVID-19 in Iraqi patients.Tzu chi medical journalArticle
- Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan.In vivo (Athens, Greece)Article
- Association of Polymorphisms in DNA Repair GeneIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B with asthma. The asthma group included 198 adult patients and the control group included 453 individuals without asthma that were frequency-matched by gender and age. The distribution of genotypic and allelic frequencies of IL-12A rs568408 demonstrated significant differences between case and control groups. Specifically, the percentages of AA genotype of IL-12A rs568408 was significantly higher among asthmatic patients in Taiwan than healthy controls, compared to GG genotype. No significant difference was observed among the IL-12A rs2243115 and IL-12B rs3212227 genotypes between case and control groups. In addition, the A allele at IL-12A rs568408 was associated with more severe symptoms (P = 0.0085) among asthmatic patients. These results suggest that IL-12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.
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