ArticleScientific reports2017
Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Dynamical interactions among protocell populations: Implications for membrane-mediated chemical evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- From experimental clues to theoretical modeling: Evolution associated with the membrane-takeover at an early stage of life.PLoS computational biology · 2025Article
- Protocell Dynamics: Modelling Growth and Division of Lipid Vesicles Driven by an Autocatalytic Reaction.Life (Basel, Switzerland) · 2025Article
- Electrophysiological Characterization of Monoolein-Fatty Acid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Concomitant formation of protocells and prebiotic compounds under a plausible early Earth atmosphere.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cyclophospholipids Enable a Protocellular Life Cycle.ACS nano · 2023Article
- Positively charged mineral surfaces promoted the accumulation of organic intermediates at the origin of metabolism.PLoS computational biology · 2022Article
- Protometabolism as out-of-equilibrium chemistry.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Review
- Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure.PLoS biology · 2021Article
- When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells.Life (Basel, Switzerland) · 2021Article
- Article
- Prebiological Membranes and Their Role in the Emergence of Early Cellular Life.The Journal of membrane biology · 2020Review
- Dynamics of the vesicles composed of fatty acids and other amphiphile mixtures: unveiling the role of fatty acids as a model protocell membrane.Biophysical reviews · 2020Article
- The Construction of Biological 'Inter-Identity' as the Outcome of a Complex Process of Protocell Development in Prebiotic Evolution.Frontiers in physiology · 2020Article
- The Informational Substrate of Chemical Evolution: Implications for Abiogenesis.Life (Basel, Switzerland) · 2019Article
- The optimal size of protocells from simple entropic considerations.European biophysics journal : EBJ · 2019Article
- Progress in synthesizing protocells.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Amphiphilic Compounds Assemble into Membranous Vesicles in Hydrothermal Hot Spring Water but Not in Seawater.Life (Basel, Switzerland) · 2018Article
- Adaptive artificial evolution of droplet protocells in a 3D-printed fluidic chemorobotic platform with configurable environments.Nature communications · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
Abstract
The origin-of-life problem has been traditionally conceived as the chemical challenge to find the type of molecule and free-solution reaction dynamics that could have started Darwinian evolution. Different autocatalytic and 'self-replicative' molecular species have been extensively investigated, together with plausible synthetic pathways that might have led, abiotically, to such a minimalist scenario. However, in addition to molecular kinetics or molecular evolutionary dynamics, other physical and chemical constraints (like compartmentalization, differential diffusion, selective transport, osmotic forces, energetic couplings) could have been crucial for the cohesion, functional integration, and intrinsic stability/robustness of intermediate systems between chemistry and biology. These less acknowledged mechanisms of interaction and molecular control might have made the initial pathways to prebiotic systems evolution more intricate, but were surely essential for sustaining far-from-equilibrium chemical dynamics, given their functional relevance in all modern cells. Here we explore a protocellular scenario in which some of those additional constraints/mechanisms are addressed, demonstrating their 'system-level' implications. In particular, an experimental study on the permeability of prebiotic vesicle membranes composed of binary lipid mixtures allows us to construct a semi-empirical model where protocells are able to reproduce and undergo an evolutionary process based on their coupling with an internal chemistry that supports lipid synthesis.
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