ArticleScientific reports2017
REG3β modifies cell tumor function by impairing extracellular vesicle uptake.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Exosomes: their role and therapeutic potential in overcoming drug resistance of gastrointestinal cancers.Frontiers in oncology · 2025Review
- Extracellular vesicles (EVs)' journey in recipient cells: from recognition to cargo release.Journal of Zhejiang University. Science. B · 2024Review
- Extracellular vesicles in pancreatic cancer: a new era in precision medicine.Translational gastroenterology and hepatology · 2024Review
- Review
- Extracellular Vesicles as "Very Important Particles" (VIPs) in Aging.International journal of molecular sciences · 2023Review
- Pancreatic cancer, stroma, and exosomes.Journal of physiology and biochemistry · 2023Article
- Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate.Cells · 2022Review
- Exosomes as Pleiotropic Players in Pancreatic Cancer.Biomedicines · 2021Review
- Article
- Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Review
- Functional proteins of mesenchymal stem cell-derived extracellular vesicles.Stem cell research & therapy · 2019Review
- The Role of Exosomes in Pancreatic Cancer.International journal of molecular sciences · 2019Review
- Analysis of extracellular vesicles generated from monocytes under conditions of lytic cell death.Scientific reports · 2019Article
- Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges.Frontiers in cell and developmental biology · 2019Review
- Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma.PloS one · 2019Article
- The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications.Cells · 2018Review
- Adding Reg3β to the acute coronary syndrome prognostic marker list.International journal of cardiology · 2018Article
- Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications.Molecular cancer · 2018Review
- Extracellular Vesicles: A New Perspective in Tumor Therapy.BioMed research international · 2018Review
- Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression.OncoimmunologyReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-sized membrane vesicles containing proteins and nucleic acids, which act as intercellular messengers. They play an important role in a variety of physiological processes, as well as in pathological situations such as inflammation or cancer. Here, we show that in the case of pancreatic ductal adenocarcinoma (PDAC), the healthy pancreatic tissue surrounding the tumor releases REG3β, a lectin that binds to the glycoproteins present in the surface of EVs, thus interfering with their uptake and internalization by target cells. In vitro, the disruption of the signaling mediated by EVs due to the presence of REG3β, prevents the EV-induced phenotypic switch in macrophages, inhibits the increased cell migration of cancer cells and reverses a number of metabolomic changes promoted by EVs. In vivo, the uptake of REG3β
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.