ArticleScientific reports2017
Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Applications of Dry Film Photoresist in Micromachining: A Review.Micromachines · 2025Review
- Recent Trends in Enzyme-Based Biosensors for On-Site Screening of Antibiotic Residues.Chemistry, an Asian journal · 2025Review
- Pursuing precision in medicine and nutrition: the rise of electrochemical biosensing at the molecular level.Analytical and bioanalytical chemistry · 2024Review
- Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine.Frontiers in pharmacology · 2024Review
- A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip.Heliyon · 2023Article
- Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Thermostable β-Lactamase Mutant with Its Active Site Conjugated with Fluorescein for Efficient β-Lactam Antibiotic Detection.ACS omega · 2019Article
- Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation.Journal of visualized experiments : JoVE · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An appropriate antibiotherapy is crucial for the safety and recovery of patients. Depending on the clinical conditions of patients, the required dose to effectively eradicate an infection may vary. An inadequate dosing not only reduces the efficacy of the antibiotic, but also promotes the emergence of antimicrobial resistances. Therefore, a personalized therapy is of great interest for improved patients' outcome and will reduce in long-term the prevalence of multidrug-resistances. In this context, on-site monitoring of the antibiotic blood concentration is fundamental to facilitate an individual adjustment of the antibiotherapy. Herein, we present a bioinspired approach for the bedside monitoring of free accessible ß-lactam antibiotics, including penicillins (piperacillin) and cephalosporins (cefuroxime and cefazolin) in untreated plasma samples. The introduced system combines a disposable microfluidic chip with a naturally occurring penicillin-binding protein, resulting in a high-performance platform, capable of gauging very low antibiotic concentrations (less than 6 ng ml
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