Evidence map›Paper›PMID 28600458›Full record

ArticleNeurology2017

Structural MRI markers of brain aging early after ischemic stroke.

Emilio Werden, Toby Cumming, Qi Li, Laura Bird, Michele Veldsman, Heath R Pardoe, Graeme Jackson, Geoffrey A Donnan, Amy Brodtmann

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Microvascular brain damage in middle-aged women with a history of migraine with aura and/or ischemic stroke.International journal of stroke : official journal of the International Stroke Society · 2026
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  10. Contextualizing molecular and structural aging across human organs.medRxiv : the preprint server for health sciences · 2025
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  14. Acceleration of brain aging after small-volume infarcts.Frontiers in aging neuroscience · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Emilio WerdenFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Toby CummingFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Qi LiFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Laura BirdFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Michele VeldsmanFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Heath R PardoeFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Graeme JacksonFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Geoffrey A DonnanFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia.
Amy BrodtmannFrom the Florey Institute of Neuroscience and Mental Health (E.W., T.C., Q.L., L.B., M.V., H.R.P., G.J., G.A.D., A.B.), University of Melbourne; Austin Health (G.J., A.B.), Heidelberg; and Eastern Clinical Research Unit (A.B.), Monash University, Box Hill Hospital, Melbourne, Victoria, Australia. agbrod@unimelb.edu.au.
Austin Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine associations between ischemic stroke, vascular risk factors, and MRI markers of brain aging.

methodsEighty-one patients (mean age 67.5 ± 13.1 years, 31 left-sided, 61 men) with confirmed first-ever (n = 66) or recurrent (n = 15) ischemic stroke underwent 3T MRI scanning within 6 weeks of symptom onset (mean 26 ± 9 days). Age-matched controls (n = 40) completed identical testing. Multivariate regression analyses examined associations between group membership and MRI markers of brain aging (cortical thickness, total brain volume, white matter hyperintensity [WMH] volume, hippocampal volume), normalized against intracranial volume, and the effects of vascular risk factors on these relationships.

resultsFirst-ever stroke was associated with smaller hippocampal volume (

conclusionsBrain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.

Indexed as

AgedAged, 80 and overAgingBiomarkersBrainBrain IschemiaFemaleFollow-Up StudiesHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedStrokeWhite MatterBiomarkers

Identifiers

PMID28600458
PMCPMC5501937
OpenAlexW2623873915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.