Evidence map›Paper›PMID 28600368›Full record

ArticleBMJ open2017

Assessing the diagnostic accuracy of PCR-based detection of

Hayley D Gillis, Amanda L S Lang, May ElSherif, Irene Martin, Todd F Hatchette, Shelly A McNeil, Jason J LeBlanc, Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research (CIRN)

Open access · goldAbstract readValidation Study
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Simultaneous Genetically Detection ofIranian journal of pathology · 2023
    Article
  4. Article
  5. Acute Respiratory Tract Infections among Hospitalized Palestinian Patients (2011-2016): A Retrospective Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021
    Article
  6. Identification of Streptococcus pneumoniae and other Mitis streptococci: importance of molecular methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Review
  7. A patient with a rapidly lethal pneumonia after a visit to a touristic area in rural Leon (Spain).Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hayley D GillisCanadian Centre for Vaccinology (CCfV), IWK Health Center, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia, Canada.
Amanda L S LangCanadian Centre for Vaccinology (CCfV), IWK Health Center, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia, Canada.
May ElSherifCanadian Centre for Vaccinology (CCfV), IWK Health Center, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia, Canada.
Irene MartinNational Microbiology Laboratory (NML), Winnipeg, Manitoba, Canada.
Todd F HatchetteCanadian Centre for Vaccinology (CCfV), IWK Health Center, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia, Canada.
Shelly A McNeilCanadian Centre for Vaccinology (CCfV), IWK Health Center, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia, Canada.
Jason J LeBlancCanadian Centre for Vaccinology (CCfV), IWK Health Center, Nova Scotia Health Authority (NSHA), and Dalhousie University, Halifax, Nova Scotia, Canada.
Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research (CIRN)
Dalhousie University · CANova Scotia Health Authority · CA

Funding

CIHR 23338
6 · The paper itself

Abstract

STUDY

designDetection and serotyping of

methodsActive surveillance for community-acquired pneumonia (CAP) in hospitalised adults was performed from December 2010 to 2013. Detection of pneumococcal CAP (CAP

resultsNP swab results were compared against CAP cases where all pneumococcal tests were performed (n=434), or where at least one test was performed (n=1616). CAP

conclusionsWhile further optimisation may be needed to increase the sensitivity of PCR-based detection, its high specificity suggests there is a value for pneumococcal surveillance. With many laboratories archiving specimens for influenza virus surveillance, this specimen type could provide a non-culture-based method for pneumococcal surveillance.

Indexed as

AdultAgedCanadaFemaleHumansMaleMiddle AgedNasopharynxPneumococcal VaccinesPneumonia, PneumococcalReal-Time Polymerase Chain ReactionSensitivity and SpecificitySerotypingStreptococcus pneumoniaeYoung AdultPneumococcal Vaccinesdetectionmolecular, nasopharyngeal swab.PCRserotypestreptococcus pneumoniae

Identifiers

PMID28600368
PMCPMC5623389
OpenAlexW2623126700

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.