Evidence map›Paper›PMID 28600365›Full record

SynthesisBMJ open2017

Effect of physical activity and dietary restriction interventions on weight loss and the musculoskeletal function of overweight and obese older adults with knee osteoarthritis: a systematic review and mixed method data synthesis.

Asma S Alrushud, Alison B Rushton, Archontissa M Kanavaki, Carolyn A Greig

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 7 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Asma S AlrushudSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Alison B RushtonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Archontissa M KanavakiSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Carolyn A GreigSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
University of Birmingham · GBKing Saud University · SA

Funding

Medical Research Council MR/K00414X/1
6 · The paper itself

Abstract

backgroundDespite the clinical recommendation of exercise and diet for people with knee osteoarthritis (OA), there are no systematic reviews synthesising the effectiveness of combining physical activity and dietary restriction interventions on the musculoskeletal function of overweight and obese older adults with knee OA.

objectiveTo evaluate the effectiveness of combined physical activity and dietary restriction programmes on body weight, body mass index (BMI) and the musculoskeletal function of overweight and obese older adults with knee OA. INFORMATION SOURCES: A detailed search strategy was applied to key electronic databases (Ovid, Embase, Web of Science andCumulative Index to Nursing and Allied Health Literature (CINAHL)) for randomised controlled trials (RCTs) published in English prior to 15 January 2017.

participantsParticipants with BMI ≥25 kg/m

interventionsPhysical activity plus dietary restriction programmes with usual care or exercise as the comparators. OUTCOME MEASURES: Primary outcome measures were body weight, BMI or musculoskeletal function. Secondary outcome measures were pain and quality of life.

resultsOne pilot and two definitive trials with n=794 participants were included. Two articles reporting additional data and outcome measures for one of the RCTs were identified. All included RCTs had an unclear risk of bias. Meta-analysis was only possible to evaluate mobility (6 min walk test) at 6 months and the pooled random effect 15.05 (95% CI -11.77 to 41.87) across two trials with n=155 participants did not support the combined intervention programme. Narrative synthesis showed clear differences in favour of a reduced body weight and an increased 6 min walk in the intervention group compared with control groups.

conclusionThe quality of evidence of benefit of combining exercise and dietary interventions in older overweight/obese adults with knee OA is unclear. TRAIL REGISTRATION NUMBER: CRD42015019088 and ISRCTN, ISRCTN12906938.

Indexed as

Diet, ReducingAgedArthralgiaBody Mass IndexBody WeightExerciseFemaleHumansMaleMiddle AgedMuscle StrengthObesityOsteoarthritis, KneeOverweightQuality of LifeRange of Motion, ArticulardietelderlyExerciseobesityrandomised controlled trials

Identifiers

PMID28600365
PMCPMC5541637
OpenAlexW2624253901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.