Evidence map›Paper›PMID 28600357›Full record

ArticleThe Journal of biological chemistry2017

The natural phosphoinositide derivative glycerophosphoinositol inhibits the lipopolysaccharide-induced inflammatory and thrombotic responses.

Mariangela Vessichelli, Stefania Mariggiò, Alessia Varone, Pasquale Zizza, Angelomaria Di Santo, Concetta Amore, Giuseppe Dell'Elba, Adele Cutignano, Angelo Fontana, Carmela Cacciapuoti and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Plasma metabolomics in infancy reveals early signatures of a stringently-defined otitis-prone phenotype.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
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  11. Ocular Surface Failure in Urban Syndrome.Journal of clinical medicine · 2021
    Article
  12. Article
  13. A signalling cascade involving receptor-activated phospholipase ACell communication and signaling : CCS · 2019
    Article
  14. Article
  15. Taurine AttenuatesFrontiers in immunology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Mariangela VessichelliInstitute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
Stefania MariggiòInstitute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
Alessia VaroneInstitute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
Pasquale ZizzaInstitute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
Angelomaria Di SantoLaboratory of Vascular Biology and Pharmacology, Consorzio and Fondazione Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy.
Concetta AmoreLaboratory of Vascular Biology and Pharmacology, Consorzio and Fondazione Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy.
Giuseppe Dell'ElbaLaboratory of Vascular Biology and Pharmacology, Consorzio and Fondazione Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy.
Adele CutignanoInstitute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy.
Angelo FontanaInstitute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy.
Carmela CacciapuotiTransfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, Istituto di Ricovero e Cura a Carattere Scientifico, Via M. Semmola 52, 80131 Naples, Italy.
Gaetano Di CostanzoTransfusion Service, Department of Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute G. Pascale Foundation, Istituto di Ricovero e Cura a Carattere Scientifico, Via M. Semmola 52, 80131 Naples, Italy.
Mariastella ZanniniInstitute of Experimental Endocrinology and Oncology, National Research Council, Via S. Pansini 5, 80131 Naples, Italy.
Tiziana de CristofaroInstitute of Experimental Endocrinology and Oncology, National Research Council, Via S. Pansini 5, 80131 Naples, Italy.
Virgilio EvangelistaLaboratory of Vascular Biology and Pharmacology, Consorzio and Fondazione Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro, Chieti, Italy. Electronic address: evangelista59gino@gmail.com.
Daniela CordaInstitute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy. Electronic address: d.corda@ibp.cnr.it.
Mario Negri Sud Foundation · ITNational Research Council · ITInstitute of Protein Biochemistry · ITInstitute for Experimental Endocrinology and Oncology · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory responses are elicited through lipid products of phospholipase A

Indexed as

Active Transport, Cell NucleusAnimalsAnticoagulantsAnti-Inflammatory Agents, Non-SteroidalBiomarkersBlood CoagulationCells, CulturedChromatin ImmunoprecipitationDose-Response Relationship, DrugEndotoxemiaGene Expression RegulationHeLa CellsHumansInositol PhosphatesLipopolysaccharidesMaleAnticoagulantsAnti-Inflammatory Agents, Non-SteroidalBiomarkersglycerylphosphoinositolInositol PhosphatesLipopolysaccharidesNF-kappa Binflammationlipid signalinglipopolysaccharide (LPS)monocyteNF-κB (NF-KB)pharmacologysecond messengersepsistissue factortranscription regulation

Identifiers

PMID28600357
PMCPMC5546025
OpenAlexW2621774274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.