Evidence map›Paper›PMID 28600306›Full record

ArticleJournal of leukocyte biology2017

Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration.

Jennifer C Brazil, Ronen Sumagin, Sean R Stowell, Goo Lee, Nancy A Louis, Richard D Cummings, Charles A Parkos

Open access · bronzeAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Glycan Markers of Pluripotent Stem Cells.Advances in experimental medicine and biology · 2026
    Review
  2. Article
  3. Review
  4. LEUKOCYTE-EPITHELIAL INTERACTIONS: A DOUBLE-EDGED SWORD THAT PROTECTS AND INJURES DURING HEALTH AND DISEASE.Transactions of the American Clinical and Climatological Association · 2022
    Article
  5. Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jennifer C BrazilDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA; brazilj@med.umich.edu.
Ronen SumaginDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Sean R StowellDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Goo LeeDepartment of Pathology, Emory University, Atlanta, Georgia, USA.
Nancy A LouisDepartment of Neonatal-Perinatal Medicine, Emory University, Atlanta, Georgia, USA; and.
Richard D CummingsDepartment of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Charles A ParkosDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Emory University · USHarvard University · USNorthwestern University · US

Funding

Intestinal Inflammation: Signaling proteins and the rate of PMN transmigrationR01DK079392 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2007 to 2025
$7.2M
Neutrophil Interactions with Intestinal Epithelial CellsR01DK072564 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2005 to 2020
$6.5M
Neutrophil interactions with apical ICAM-1 regulate intestinal epithelial homeostK01DK101675 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SUMAGIN, RONEN · 2014 to 2018
$710k
NIDDK NIH HHS K01 DK101675NIDDK NIH HHS R01 DK072564NIDDK NIH HHS R01 DK079392
6 · The paper itself

Abstract

PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Le

Indexed as

Immunity, InnateImmunity, MucosalCaco-2 CellsCoculture TechniquesGene Expression RegulationHumansLewis Blood Group AntigensNeutrophilsOligosaccharidesTransendothelial and Transepithelial MigrationLewis a oligosaccharideLewis Blood Group AntigensOligosaccharidesmucosal inflammationneutrophil activationtransepithelial migration

Identifiers

PMID28600306
PMCPMC5557642
OpenAlexW2624640804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.