Evidence map›Paper›PMID 28600200›Full record

ReviewArchives of biochemistry and biophysics2017

Applications of NMR to structure determination of RNAs large and small.

Ravi P Barnwal, Fan Yang, Gabriele Varani

Open access · greenAbstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 134 citations in OpenAlex.

  1. Structural and biophysical insights into the unique RNase YicC.bioRxiv : the preprint server for biology · 2026
    Article
  2. Folding and unfolding dynamics of a DNA aptamer studied by heteronuclearJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Application of NMR to Large RNAs.Journal of molecular biology · 2025
    Review
  9. Review
  10. Selective [9-Chembiochem : a European journal of chemical biology · 2025
    Article
  11. Investigation of anti-microbial and cytotoxic potential of Streptomyces werraensis GRS9 derived from the sediments of river Ganga.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Identification of RNA structures and their roles in RNA functions.Nature reviews. Molecular cell biology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ravi P BarnwalDepartment of Chemistry, University of Washington, Seattle 98195, WA, USA.
Fan YangDepartment of Chemistry, University of Washington, Seattle 98195, WA, USA.
Gabriele VaraniDepartment of Chemistry, University of Washington, Seattle 98195, WA, USA. Electronic address: varani@chem.washington.edu.
University of Washington · US

Funding

Regulation of microRNA processingR01GM103834 · NIGMS · UNIVERSITY OF WASHINGTON · PI VARANI, GABRIELE · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM103834
6 · The paper itself

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to investigate the structure and dynamics of RNA, because many biologically important RNAs have conformationally flexible structures, which makes them difficult to crystallize. Functional, independently folded RNA domains, range in size between simple stem-loops of as few as 10-20 nucleotides, to 50-70 nucleotides, the size of tRNA and many small ribozymes, to a few hundred nucleotides, the size of more complex RNA enzymes and of the functional domains of non-coding transcripts. In this review, we discuss new methods for sample preparation, assignment strategies and structure determination for independently folded RNA domains of up to 100 kDa in molecular weight.

Indexed as

Molecular WeightNuclear Magnetic Resonance, BiomolecularRNARNAIsotope labelingNMR spectroscopyRNAStructure

Identifiers

PMID28600200
PMCPMC5555312
OpenAlexW2625082919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.