Trial reportThe Journal of pediatrics2017
Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation.
Trial report in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00233324 (Surfactant Positive Airway Pressure and Pulse Oximetry Trial), which is not on this map. Cited by 71 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) in Extremely Low Birth Weight Infants
Who cites it
71 citing papers in PubMed, 6 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Lung ultrasound aeration score as a predictor of extubation failure in neonates: an updated systematic review with meta-analysis and meta-regression.European journal of pediatrics · 2026Pooled it
- Postextubation use of non-invasive respiratory support in preterm infants: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Peri-extubation settings in preterm neonates: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2024Pooled it
- Predictors of extubation failure in newborns: a systematic review and meta-analysis.Italian journal of pediatrics · 2023Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.Neonatology · 2023Guideline
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.Neonatology · 2019Guideline
- Effect of different maintenance doses of caffeine citrate on ventilator weaning in very preterm infants with respiratory distress syndrome: a prospective randomized controlled trial.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- [Clinical effect of an additional maintenance dose of caffeine before ventilator weaning in preterm infants with respiratory distress syndrome: a prospective randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- Comparison of extubation success using noninvasive positive pressure ventilation (NIPPV) versus noninvasive neurally adjusted ventilatory assist (NI-NAVA).Journal of perinatology : official journal of the California Perinatal Association · 2020Trial
- Lung Ultrasound in Bronchopulmonary Dysplasia: Diagnostic Tool, Prognostic Marker or Monitoring Strategy?Children (Basel, Switzerland) · 2026Review
- Physiologic signatures during extubation readiness trials in neonates >35 weeks' postmenstrual age.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- The effect of postnatal steroids on lung ultrasound scores and extubation readiness in very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Impact of the neonatal intensive critical ultrasound workflow for managing neonatal acute pulmonary hypertension.Frontiers in pediatrics · 2026Article
- Nomogram-based prediction model for extubation failure in preterm infants with invasive mechanical ventilation.Italian journal of pediatrics · 2025Article
- Sonographic evaluation of lungs and diaphragm as a predictor for extubation failure in early preterm neonates: a prospective diagnostic accuracy study.European journal of pediatrics · 2025Article
- AI models in clinical neonatology: a review of modeling approaches and a consensus proposal for standardized reporting of model performance.Pediatric research · 2025Review
- Predictive model development for premature infant extubation outcomes: development and analysis.Pediatric research · 2025Article
- Accuracy of lung ultrasound in predicting successful extubation in preterm infants born ≤ 25 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Interprofessional perspectives on non-invasive respiratory support practices in extremely preterm infants: a Canadian survey.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Predicting extubation failure in neonates: The role of lung ultrasound and corrected gestational age in safe weaning in the NICU.European journal of pediatrics · 2025Observational
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
objectivesTo identify variables associated with successful elective extubation, and to determine neonatal morbidities associated with extubation failure in extremely preterm neonates. STUDY
designThis study was a secondary analysis of the National Institute of Child Health and Human Development Neonatal Research Network's Surfactant, Positive Pressure, and Oxygenation Randomized Trial that included extremely preterm infants born at 24
resultsOf 1316 infants in the trial, 1071 were eligible; 926 infants had data available on extubation status; 538 were successful and 388 failed extubation. The rate of successful extubation was 50% (188/374) in the continuous positive airway pressure group and 63% (350/552) in the surfactant group. Successful extubation was associated with higher 5-minute Apgar score, and pH prior to extubation, lower peak fraction of inspired oxygen within the first 24 hours of age and prior to extubation, lower partial pressure of carbon dioxide prior to extubation, and non-small for gestational age status after adjustment for the randomization group assignment. Infants who failed extubation had higher adjusted rates of mortality (OR 2.89), bronchopulmonary dysplasia (OR 3.06), and death/ bronchopulmonary dysplasia (OR 3.27).
conclusionsHigher 5-minute Apgar score, and pH prior to extubation, lower peak fraction of inspired oxygen within first 24 hours of age, lower partial pressure of carbon dioxide and fraction of inspired oxygen prior to extubation, and nonsmall for gestational age status were associated with successful extubation. Failed extubation was associated with significantly higher likelihood of mortality and morbidities.
trial registrationClinicalTrials.gov: NCT00233324.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.