Evidence map›Paper›PMID 28600000›Full record

ArticleBehavioural brain research2017

Sex-specific effects of developmental alcohol exposure on cocaine-induced place preference in adulthood.

Victoria A Macht, Sandra J Kelly, Justin T Gass

Abstract read
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In one paragraph

Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victoria A MachtDepartment of Psychology, University of South Carolina, Columbia, SC 29208, USA. Electronic address: victoria.macht@uscmed.sc.edu.
Sandra J KellyDepartment of Psychology, University of South Carolina, Columbia, SC 29208, USA.
Justin T GassDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.

Funding

ALCOHOL EXPOSURE, SOCIAL BEHAVIOR AND DEVELOPMENTR01AA011566 · NIAAA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KELLY, SANDRA J · 1998 to 2010
$3.2M
Interactions Between Chronic Alcohol Exposure and Fear MemoriesR01AA024526 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GASS, JUSTIN T · 2016 to 2020
$1.7M
The Role of mGluR5 Receptors in Extinction Learning of Alcohol CuesR00AA020537 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GASS, JUSTIN T · 2013 to 2015
$732k
NIAAA NIH HHS R00 AA020537NIAAA NIH HHS R01 AA011566NIAAA NIH HHS R01 AA024526
6 · The paper itself

Abstract

Fetal Alcohol Syndrome (FAS) is associated with high rates of drug addiction in adulthood. One possible basis for increased drug use in this population is altered sensitivity to drug-associated contexts. This experiment utilized a rat model of FASD to examine behavioral and neural changes in the processing of drug cues in adulthood. Alcohol was given by intragastric intubation to pregnant rats throughout gestation and to rat pups during the early postnatal period (ET group). Controls consisted of a non-treated group (NC) and a pair-fed group given the intubation procedure without alcohol (IC). On postnatal day (PD) 90, rats from all treatment groups were given saline, 0.3mg/kg, 3.0mg/kg, or 10.0mg/kg cocaine pairings with a specific context in the conditioned place preference (CPP) paradigm. While control animals of both sexes showed cocaine CPP at the 3.0 and 10.0mg/kg doses, ET females also showed cocaine CPP at 0.3mg/kg. This was accompanied by a decrease in c-Fos/GAD

Indexed as

Sex CharacteristicsAnimalsCentral Nervous System DepressantsCocaineConditioning, PsychologicalDopamine Uptake InhibitorsDose-Response Relationship, DrugEthanolFetal Alcohol Spectrum DisordersGABAergic NeuronsMaleNucleus AccumbensPrefrontal CortexRats, Long-EvansSpatial BehaviorVentral Tegmental AreaCentral Nervous System DepressantsCocaineDopamine Uptake InhibitorsEthanolAddictionCocaineFetal alcoholNucleus accumbensPlace preferencePrefrontal cortex

Identifiers

PMID28600000
PMCPMC5570610

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.