Observational studyAmerican journal of obstetrics and gynecology2017
Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes.
Observational study in American journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
91 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Sleep disturbance and its associated factors among pregnant women in Ethiopia: systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Association between sleep duration during pregnancy and gestational diabetes mellitus: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Non-pharmacological Interventions for Improving Sleep Quality During Pregnancy: A Systematic Review and Meta-Analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Pooled it
- Maternal sleep during pregnancy and adverse pregnancy outcomes: A systematic review and meta-analysis.Journal of diabetes investigation · 2022Pooled it
- Impact of objectively-measured sleep duration on cardiometabolic health: A systematic review of recent evidence.Frontiers in endocrinology · 2022Pooled it
- Eye-mask and earplugs as sleep aid on glucose metabolism in sleep-deprived pregnancy: a randomized controlled trial.BMC pregnancy and childbirth · 2026Trial
- Preconception sleep, pregnancy loss, and adverse pregnancy outcomes among women with a history of pregnancy loss.Human reproduction (Oxford, England) · 2025Trial
- Trial
- Pilot study of sleep and meal timing effects, independent of sleep duration and food intake, on insulin sensitivity in healthy individuals.Sleep health · 2018Trial
- Sleep Disorders in Pregnant Women and Their Impact on Maternal and Fetal Outcomes: A Narrative Review.Journal of clinical medicine · 2026Review
- Sleep Disruption, Psychological Stress, and Preeclampsia in High-Risk Pregnancies During the COVID-19 Era.Life (Basel, Switzerland) · 2026Article
- Natural environment and gestational diabetes risk in Australia: a spatiotemporal ecological regression approach.BMC public health · 2026Article
- Dual-center prospective validation of an early second-trimester predictive model integrating BMI trajectories and pathophysiological biomarkers for gestational diabetes risk stratification.Journal of diabetes investigation · 2026Article
- Predictors of infant birth weights: Role of the Lebanese mediterranean diet, psychosocial factors and maternal health status.PloS one · 2026Article
- Sleepiness in pregnancy and adverse perinatal outcomes.Pregnancy (Hoboken, N.J.) · 2026Article
- Article
- Sleep variability and time to achieving pregnancy: findings from a pilot cohort study of women desiring pregnancy.Fertility and sterility · 2025Article
- Relationship between multidimensional sleep health and depression during late pregnancy: a cross-sectional study.BMC psychiatry · 2025Article
- Sleeping for two: a cross-sectional study on associations between objectively measured sleep during early to mid-pregnancy and maternal and fetal outcomes and inflammatory biomarker profiles.BMC pregnancy and childbirth · 2025Article
- Diary- and actigraphy-estimated nighttime sleep during the perinatal period: A multimethod study.Journal of behavioral medicine · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundExperimental and epidemiologic data suggest that among nonpregnant adults, sleep duration may be an important risk factor for chronic disease. Although pregnant women commonly report poor sleep, few studies objectively evaluated the quality of sleep in pregnancy or explored the relationship between sleep disturbances and maternal and perinatal outcomes.
objectiveOur objective was to examine the relationship between objectively assessed sleep duration, timing, and continuity (measured via wrist actigraphy) and maternal cardiovascular and metabolic morbidity specific to pregnancy. STUDY
designThis was a prospective cohort study of nulliparous women. Women were recruited between 16 0/7 and 21 6/7 weeks' gestation. They were asked to wear a wrist actigraphy monitor and complete a daily sleep log for a period of 7 consecutive days. The primary sleep exposure variables were the averages of the following over the total valid nights (minimum 5, maximum 7 nights): short sleep duration during the primary sleep period (<7 h/night), late sleep midpoint (midpoint between sleep onset and sleep offset >5 am), and top quartile of minutes of wake time after sleep onset and sleep fragmentation index. The primary outcomes of interest were a composite of hypertensive disorders of pregnancy (mild, severe, or superimposed preeclampsia; eclampsia; or antepartum gestational hypertension) and gestational diabetes mellitus. We used χ
resultsIn all, 901 eligible women consented to participate; 782 submitted valid actigraphy studies. Short sleep duration and a later sleep midpoint were associated with an increased risk of gestational diabetes (odds ratio, 2.24; 95% confidence interval, 1.11-4.53; and odds ratio, 2.58; 95% confidence interval, 1.24-5.36, respectively) but not of hypertensive disorders. A model with both sleep duration and sleep midpoint as well as their interaction term revealed that while there was no significant interaction between these exposures, the main effects of both short sleep duration and later sleep midpoint with gestational diabetes remained significant (adjusted odds ratio, 2.06; 95% confidence interval, 1.01-4.19; and adjusted odds ratio, 2.37; 95% confidence interval, 1.13-4.97, respectively). Additionally, after adjusting separately for age, body mass index, and race/ethnicity, both short sleep duration and later sleep midpoint remained associated with gestational diabetes. No associations were demonstrated between the sleep quality measures (wake after sleep onset, sleep fragmentation) and hypertensive disorders or gestational diabetes.
conclusionOur results demonstrate a relationship between short sleep duration and later sleep midpoint with gestational diabetes. Our data suggest independent contributions of these 2 sleep characteristics to the risk for gestational diabetes in nulliparous women.
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