Evidence map›Paper›PMID 28599865›Full record

ArticleLife sciences2017

Estrogen receptor α activation enhances its cell surface localization and improves myocardial redox status in ovariectomized rats.

Rebecca J Steagall, Fanrong Yao, Saame Raza Shaikh, Abdel A Abdel-Rahman

Open access · greenAbstract read
In one paragraph

Article in Life sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Estrogen elicits ferroptosis-related myocardial oxidative stress and dysfunction in male rats.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022
    Review
  6. Review
  7. Article
  8. Review
  9. The comparative toxicity ofToxicon: X · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress.Translational research : the journal of laboratory and clinical medicine · 2018
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebecca J SteagallDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Fanrong YaoDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Saame Raza ShaikhDepartment of Biochemistry and Molecular Biology, East Carolina Diabetes & Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Abdel A Abdel-RahmanDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: abdelrahmana@ecu.edu.
East Carolina University · US

Funding

Sex/estrogen-dependent vulnerability to alcohol-evoked cardiotoxicity: Role of circadian rhythm regulated enzymesR01AA014441 · NIAAA · EAST CAROLINA UNIVERSITY · PI ABDEL-RAHMAN, ABDEL A · 2004 to 2022
$5.2M
NIAAA NIH HHS R01 AA014441
6 · The paper itself

Abstract

aimsLittle is known about the role of subcellular trafficking of estrogen receptor (ER) subtypes in the acute estrogen (E MAIN

methodsMyocardial distribution of subcellular ERα, ERβ and G-protein coupled estrogen receptor (GPER) was determined in proestrus sham-operated (SO) and in ovariectomized (OVX) rats, acutely treated with E KEY

findingsCompared with SO, OVX rats exhibited higher myocardial ROS and MDA levels, reduced catalase and SOD activities, along with diminished ERα, and enhanced ERβ and GPER, localization at cardiomyocyte membrane. Acute E SIGNIFICANCE: The findings highlight ERα agonists as potential therapeutics for restoring the myocardial redox status following E

Indexed as

Oxidation-ReductionOxidative StressAnimalsEstrogen Receptor alphaEstrogen Receptor betaEstrogensFemaleMyocardiumMyocytes, CardiacOvariectomyRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledSuperoxide DismutaseEstrogen Receptor alphaEstrogen Receptor betaEstrogensGper1 protein, ratReceptors, G-Protein-CoupledSuperoxide DismutaseEstrogen receptor αMyocardiumRedox status

Identifiers

PMID28599865
PMCPMC5535783
OpenAlexW2622867643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.