ArticleMicrobial cell factories2017
Microtiter plate cultivation of oleaginous fungi and monitoring of lipogenesis by high-throughput FTIR spectroscopy.
Article in Microbial cell factories, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Hybrid Biomass From Co-Culturing Filamentous Fungi on Food Waste for Alternative Leather Material Production.Microbial biotechnology · 2026Article
- Vibrational spectroscopy methodology for profiling of mixed carbon metabolism in carotenogenic and oleaginous Mucor circinelloides.Microbial cell factories · 2026Article
- Polyunsaturated fatty acids in biotechnology and health: Sources, Synthesis, Applications, and market trends.Archives of microbiology · 2026Review
- Application of vibrational spectroscopies as process analytical techniques for monitoring fermentation and the conversion of lignocellulosic biomass by oleaginous filamentous fungi.Microbial cell factories · 2025Article
- Effect of hydrogen peroxide and carbon-to-nitrogen ratio on growth and biochemical profile in oleaginous mucoromycota.Microbial cell factories · 2025Article
- Enhanced co-production of extracellular biopolymers and intracellular lipids by Rhodotorula using lignocellulose hydrolysate and fish oil by-product urea.Biotechnology for biofuels and bioproducts · 2025Article
- Simultaneous production of fatty acids and amino polysaccharides from Norway spruce hydrolysates using oleaginous Mucor circinelloides.Scientific reports · 2025Article
- Compatible traits of oleaginous Mucoromycota fungi for lignocellulose-based simultaneous saccharification and fermentation.Biotechnology for biofuels and bioproducts · 2025Article
- Effects of nitrogen starvation on growth and biochemical composition of some microalgae species.Folia microbiologica · 2024Article
- Oleaginous fungi: a promising source of biofuels and nutraceuticals with enhanced lipid production strategies.Archives of microbiology · 2024Review
- Explorative characterization and taxonomy-aligned comparison of alterations in lipids and other biomolecules in Antarctic bacteria grown at different temperatures.Environmental microbiology reports · 2024Article
- Global biochemical profiling of fast-growing Antarctic bacteria isolated from meltwater ponds by high-throughput FTIR spectroscopy.PloS one · 2024Article
- Raman spectroscopy online monitoring of biomass production, intracellular metabolites and carbon substrates during submerged fermentation of oleaginous and carotenogenic microorganisms.Microbial cell factories · 2023Article
- Sustainable biosynthesized bimetallic ZnO@SeO nanoparticles from pomegranate peel extracts: antibacterial, antifungal and anticancer activities.RSC advances · 2023Article
- Multiscale spectroscopic analysis of lipids in dimorphic and oleaginous Mucor circinelloides accommodate sustainable targeted lipid production.Fungal biology and biotechnology · 2023Article
- The Ground-Based BIOMEX Experiment Verification Tests for Life Detection on Mars.Life (Basel, Switzerland) · 2021Article
- Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex.BMC biology · 2021Article
- Assessment of Biotechnologically Important Filamentous Fungal Biomass by Fourier Transform Raman Spectroscopy.International journal of molecular sciences · 2021Article
- Bioreactor Co-Cultivation of High Lipid and Carotenoid Producing YeastMicroorganisms · 2021Article
- Calcium Affects Polyphosphate and Lipid Accumulation in Mucoromycota Fungi.Journal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
11 authors.
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Abstract
backgroundOleaginous fungi can accumulate lipids by utilizing a wide range of waste substrates. They are an important source for the industrial production of omega-6 polyunsaturated fatty acids (gamma-linolenic and arachidonic acid) and have been suggested as an alternative route for biodiesel production. Initial research steps for various applications include the screening of fungi in order to find efficient fungal producers with desired fatty acid composition. Traditional cultivation methods (shake flask) and lipid analysis (extraction-gas chromatography) are not applicable for large-scale screening due to their low throughput and time-consuming analysis. Here we present a microcultivation system combined with high-throughput Fourier transform infrared (FTIR) spectroscopy for efficient screening of oleaginous fungi.
resultsThe microcultivation system enables highly reproducible fungal fermentations throughout 12 days of cultivation. Reproducibility was validated by FTIR and HPLC data. Analysis of FTIR spectral ester carbonyl peaks of fungal biomass offered a reliable high-throughput at-line method to monitor lipid accumulation. Partial least square regression between gas chromatography fatty acid data and corresponding FTIR spectral data was used to set up calibration models for the prediction of saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, unsaturation index, total lipid content and main individual fatty acids. High coefficients of determination (R
conclusionsWe have demonstrated in this study, that the presented microcultivation system combined with rapid, high-throughput FTIR spectroscopy is a suitable screening platform for oleaginous fungi. Sample preparation for FTIR measurements can be automated to further increase throughput of the system.
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