Evidence map›Paper›PMID 28599629›Full record

Trial reportBMC anesthesiology2017

Dose-dependent effects of intravenous methoxamine infusion during hip-joint replacement surgery on postoperative cognitive dysfunction and blood TNF-α level in elderly patients: a randomized controlled trial.

Shenghui Sun, Defeng Sun, Lin Yang, Jun Han, Ruochuan Liu, Lijie Wang

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shenghui SunAffiliated High School of Liaoning Normal University, Dalian, People's Republic of China.
Defeng SunDepartment of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, No.222 ZhongshanRoad, Xigang District, Dalian, 116011, Liaoning, People's Republic of China. sundefengyl@163.com.ORCID 0000-0002-5147-2409
Lin YangDepartment of Neuroelectrophysiology, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Jun HanDepartment of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, No.222 ZhongshanRoad, Xigang District, Dalian, 116011, Liaoning, People's Republic of China.
Ruochuan LiuDepartment of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, No.222 ZhongshanRoad, Xigang District, Dalian, 116011, Liaoning, People's Republic of China.
Lijie WangDepartment of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, No.222 ZhongshanRoad, Xigang District, Dalian, 116011, Liaoning, People's Republic of China.
Dalian Medical University · CNLiaoning Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative cognitive dysfunction (POCD), common in elderly patients, is thought to be closely associated with intraoperative instability of hemodynamics and excessive excretion of tumor necrosis factor-α (TNF-α). Methoxamine is a blood-pressure increasing drug commonly used for maintaining intraoperative hemodynamics. Methoxamine potentially promotes TNF-α expression, leading to an increased risk of POCD. This study aimed to investigate the dose-dependent effect of methoxamine on the incidence of early POCD and blood TNF-α level.

methodsThis single-center prospective double-blind controlled clinical trial included a total of 300 adult patients (75-90 years old, American Society of Anesthesiologists class II-III) who underwent unilateral hip-joint replacement surgery under epidural anesthesia. Patients were randomly divided into three methoxamine groups (M1, M2, and M3), and one control group (n = 75 per group). During surgery, M1, M2, and M3 patients received intravenous infusion of methoxamine at 2, 3, or 4 μg·kg

resultsThe primary outcome of this study was the incidence of POCD, which was higher in the M3 group (18.7%) than in the control group (5.3%), the M1 group (6.7%), or the M2 group (6.7%) (all P < 0.05). The secondary outcomes were the postoperative blood TNF-α level and intraoperative hemodynamic parameters. The postoperative TNF-α level was found to be higher than baseline in all groups and was highest in M3 patients (P < 0.05). The intraoperative hemodynamic parameters showed improved stability in the M1 and M2 groups compared with the control group. However, in the M3 group, abnormally increased intraoperative blood pressure, cardiac output, and systolic stroke volume were observed.

conclusionsIntravenous infusion of methoxamine at 2-3 μg·kg

trial registrationChinese Clinical Trial Register (Unique identifier: ChiCTR-INR-15007607 , retrospectively registered 18 Dec 2015).

Indexed as

Aged, 80 and overAnesthesia, EpiduralArthroplasty, Replacement, HipBlood PressureCardiac OutputCognitive DysfunctionDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInfusions, IntravenousMaleMethoxaminePostoperative ComplicationsProspective StudiesStroke VolumeMethoxamineTumor Necrosis Factor-alphaVasoconstrictor AgentsElderly patientsHip-joint replacement surgeryMethoxaminePostoperative cognitive dysfunctionTumor necrosis factor-α

Identifiers

PMID28599629
PMCPMC5466783
OpenAlexW2622188577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.