Evidence map›Paper›PMID 28599602›Full record

ArticleJournal of neurotrauma2018

Spinal Cord Injury Causes Systolic Dysfunction and Cardiomyocyte Atrophy.

Jordan W Squair, Kathryn M DeVeau, Kathryn A Harman, Malihe-Sadat Poormasjedi-Meibod, Brian Hayes, Jie Liu, David S K Magnuson, Andrei V Krassioukov, Christopher R West

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03924388 (The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03924388 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2022Enrolled46ConditionsSpinal Cord Injuries, Autonomic Dysreflexia, Orthostatic Hypotension, DysautonomicArmsEpidural spinal cord stimulation, Trnascutaneous electrical spinal cord stimulation.
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jordan W Squair1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
Kathryn M DeVeau1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
Kathryn A Harman1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
Malihe-Sadat Poormasjedi-Meibod1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
Brian Hayes1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
Jie Liu1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
David S K Magnuson5 Kentucky Spinal Cord Injury Research Center, University of Louisville , Louisville, Kentucky.
Andrei V Krassioukov1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
Christopher R West1 International Collaboration on Repair Discoveries, University of British Columbia , Vancouver, British Columbia, Canada .
University of British Columbia · CAInternational Collaboration On Repair Discoveries · CAUniversity of Louisville · US

Funding

Re-training locomotor circuitry in a rat model of spinal cord injuryR56NS052292 · NINDS · UNIVERSITY OF LOUISVILLE · PI MAGNUSON, DAVID SK · 2011 to 2011
$373k
NINDS NIH HHS R56 NS052292
6 · The paper itself

Abstract

Individuals with spinal cord injury (SCI) have been shown to exhibit systolic, and to a lesser extent, diastolic cardiac dysfunction. However, previous reports of cardiac dysfunction in this population are confounded by the changing loading conditions after SCI and as such, whether cardiac dysfunction per se is present is still unknown. Therefore, our aim was to establish if load-independent cardiac dysfunction is present after SCI, to understand the functional cardiac response to SCI, and to explore the changes within the cellular milieu of the myocardium. Here, we applied in vivo echocardiography and left-ventricular (LV) pressure-volume catheterization with dobutamine infusions to our Wistar rodent model of cardiac dysfunction 5 weeks following high (T2) thoracic contusion SCI, while also examining the morphological and transcriptional alterations of cardiomyocytes. We found that SCI significantly impairs systolic function independent of loading conditions (end-systolic elastance in control: 1.35 ± 0.15; SCI: 0.65 ± 0.19 mm Hg/μL). The reduction in contractile indices is accompanied by a reduction in width and length of cardiomyocytes as well as alterations in the LV extracellular matrix. Importantly, we demonstrate that the reduction in the rate (dP/dt

Indexed as

AnimalsAtrophyCardiac OutputMaleMyocytes, CardiacRatsRats, WistarSpinal Cord InjuriesStroke VolumeVentricular Function, Leftcontractilitypressure-volume relationshipspinal cord injurysympathetic nervous systemventricular function

Identifiers

PMID28599602
PMCPMC9836687
OpenAlexW2622530926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.