ArticleJournal of neurotrauma2018
Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.
Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Combined skin injury model from airblast overpressure and seawater immersion in rats: establishment, characterization, and mechanistic insights.Journal of molecular histology · 2025Article
- Temporal Dynamics of Retinal Inflammation Following Blast Exposure in a Ferret Model.Neurotrauma reports · 2025Article
- Single-cell proteomics delineates murine systemic immune response to blast lung injury.Communications biology · 2024Article
- Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries.Experimental neurology · 2024Article
- A Tropomycin-Related Kinase B Receptor Activator for the Management of Ocular Blast-Induced Vision Loss.Journal of neurotrauma · 2021Article
- Axonopathy precedes cell death in ocular damage mediated by blast exposure.Scientific reports · 2021Article
- Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies.Experimental eye research · 2021Review
- The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent.Investigative ophthalmology & visual science · 2021Article
- Proteomic Analysis Revealed the Characteristics of Key Proteins Involved in the Regulation of Inflammatory Response, Leukocyte Transendothelial Migration, Phagocytosis, and Immune Process during Early Lung Blast Injury.Oxidative medicine and cellular longevity · 2021Article
- Visual Outcomes in Experimental Rodent Models of Blast-Mediated Traumatic Brain Injury.Frontiers in molecular neuroscience · 2021Review
- Sex Does Not Influence Visual Outcomes After Blast-Mediated Traumatic Brain Injury but IL-1 Pathway Mutations Confer Partial Rescue.Investigative ophthalmology & visual science · 2020Article
- Article
- Using BXD mouse strains in vision research: A systems genetics approach.Molecular vision · 2020Review
- A Moderate Blast Exposure Results in Dysregulated Gene Network Activity Related to Cell Death, Survival, Structure, and Metabolism.Frontiers in neurology · 2020Article
- RNA sequencing profiling of the retina in C57BL/6J and DBA/2J mice: Enhancing the retinal microarray data sets from GeneNetwork.Molecular vision · 2019Article
- CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway.Oxidative medicine and cellular longevity · 2019Article
- A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks.Frontiers in neuroscience · 2019Article
- Genomic Locus Modulating IOP in the BXD RI Mouse Strains.G3 (Bethesda, Md.) · 2018Article
- Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse.Experimental eye research · 2018Article
- Optic nerve regeneration in the mouse is a complex trait modulated by genetic background.Molecular vision · 2018Article
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Authors and funding
8 authors.
Funding
Abstract
Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast injury. We observe that almost 40% of genes are differentially expressed with a false discovery rate (FDR) of <0.001, even though the nominal changes in RNA expression are rather small. Moreover, we find through machine learning approaches that genetic networks related to the innate and acquired immune system are activated. Accompanied by lymphocyte invasion into the inner retina, blast injury also results in progressive loss of visual function and retinal ganglion cells (RGCs). Collectively, these data demonstrate how systems genetics can be used to put meaning to the transcriptome changes following ocular blast injury that eventually lead to blindness.
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