Evidence map›Paper›PMID 28599462›Full record

ArticleOncology letters2017

Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function.

Ayako Ichikawa, Hiroaki Miyoshi, Fumiko Arakawa, Junichi Kiyasu, Kensaku Sato, Daisuke Niino, Yoshizo Kimura, Maki Yoshida, Riko Kawano, Hiroko Muta and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ayako IchikawaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Hiroaki MiyoshiDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Fumiko ArakawaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Junichi KiyasuDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Kensaku SatoBiostatistics Center, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Daisuke NiinoDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Yoshizo KimuraDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Maki YoshidaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Riko KawanoDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Hiroko MutaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Yasuo SugitaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Koichi OhshimaDepartment of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan.
Kurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human T-cell lymphotropic virus type (HTLV)-1 Tax is a viral protein that has been reported to be important in the proliferation of adult T-cell leukemia/lymphoma (ATLL) cells and to be a target of HTLV-1-specific cytotoxic T lymphocytes (CTLs). However, it is not clear how Tax-specific CTLs behave in lymph nodes of ATLL patients. The present study analyzed the immunostaining of Tax-specific CTLs. Furthermore, ATLL tumor cells are known to be positive for forkhead box P3 (Foxp3)and to have a regulatory T (Treg)-cell-like function. The association between T-reg function and number and activity of Tax-specific CTLs was also investigated. A total of 15 ATLL lymphoma cases with human leukocyte antigen (HLA)-A24, for which Tax has a high affinity, were selected from the files of the Department of Pathology, School of Medicine, Kurume University (Kurume, Japan) using a polymerase chain reaction (PCR) method. Immunostaining was performed for cluster of differentiation (CD) 20, CD3, CD4, CD8, T-cell intracellular antigen-1 and Foxp3 in paraffin sections, and for Tax, interferon γ and HLA-A24 in frozen sections. In addition, the staining of Tax-specific CTLs (HLA-A24-restricted) was analyzed by MHC Dextramer

Indexed as

adult T-cell leukemia/lymphomaFoxp3human T-cell lymphotropic virusregulatory T-cellTax-specific cytotoxic T-cell

Identifiers

PMID28599462
PMCPMC5453040
OpenAlexW2606086377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.