ArticleEnvironmental health perspectives2017
House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies.
Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association between house dust endotoxin and kidney injury: findings from the national health and nutrition examination survey (NHANES) 2005-2006.International urology and nephrology · 2024Article
- Cigarette Smoking, and Blood Monocyte Count Correlate with Chronic Lung Injuries and Mortality.International journal of chronic obstructive pulmonary disease · 2023Article
- Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study.The European respiratory journal · 2020Article
- Validation of Questionnaire-based Case Definitions for Chronic Obstructive Pulmonary Disease.Epidemiology (Cambridge, Mass.) · 2020Article
- Oral antimicrobial activity weakened in children with electronic waste lead exposure.Environmental science and pollution research international · 2020Article
- Endotoxin andEnvironmental health perspectives · 2019Article
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12 authors.
Funding
Abstract
backgroundThe peripheral leukocyte count is a biomarker of inflammation and is associated with human all-cause mortality. Although causes of acute leukocytosis are well-described, chronic environmental determinants of leukocyte number are less well understood.
objectivesWe investigated the relationship between house dust endotoxin concentration and peripheral leukocyte counts in human subjects.
methodsThe endotoxin–leukocyte relationship was evaluated by linear regression in the National Health and Nutrition Examination Survey (NHANES) 2005–2006 (n=6,254) and the Agricultural Lung Health Study (ALHS; n=1,708). In the ALHS, we tested for a gene [Toll-like Receptor 4 (
resultsThere is a statistically significant, positive association between endotoxin concentration and total leukocyte number [estimated change, 0.186×10
conclusionsThis is, to our knowledge, the first report of an association between house dust endotoxin and leukocyte count in a national survey. The finding was replicated in a farming population. Peripheral leukocyte count may be influenced by residential endotoxin exposure in diverse settings. https://doi.org/10.1289/EHP661.
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