Evidence map›Paper›PMID 28599142›Full record

ArticleSocial science & medicine (1982)2017

Opioid pharmacovigilance: A clinical-social history of the changes in opioid prescribing for patients with co-occurring chronic non-cancer pain and substance use.

Kelly R Knight, Margot Kushel, Jamie S Chang, Kara Zamora, Rachel Ceasar, Emily Hurstak, Christine Miaskowski

Abstract read
In one paragraph

Article in Social science & medicine (1982), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kelly R KnightUniversity of California - San Francisco, United States. Electronic address: kelly.knight@ucsf.edu.
Margot KushelUniversity of California - San Francisco, United States.
Jamie S ChangUniversity of California - San Francisco, United States.
Kara ZamoraUnited States Veteran's Administration - San Francisco, United States.
Rachel CeasarUniversity of Witwatersrand, School of Public Health, Johannesburg, South Africa.
Emily HurstakUniversity of California - San Francisco, United States.
Christine MiaskowskiUniversity of California - San Francisco, United States.

Funding

Examining the Consequences of Reductions in Opioid Prescribing on Patients, Clinical Care, and Community HealthR01DA043631 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KNIGHT, KELLY RAY · 2017 to 2021
$2.7M
Pain Management in the Clinic & CommunityR01DA034625 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KNIGHT, KELLY RAY · 2013 to 2015
$893k
NIDA NIH HHS R01 DA034625NIDA NIH HHS R01 DA043631
6 · The paper itself

Abstract

There is growing concern among US-based clinicians, patients, policy makers, and in the media about the personal and community health risks associated with opioids. Perceptions about the efficacy and appropriateness of opioids for the management of chronic non-cancer pain (CNCP) have dramatically transformed in recent decades. Yet, there is very little social scientific research identifying the factors that have informed this transformation from the perspectives of prescribing clinicians. As part of an on-going ethnographic study of CNCP management among clinicians and their patients with co-occurring substance use, we interviewed 23 primary care clinicians who practice in safety-net clinical settings. In this paper, we describe the clinical and social influences informing three historic periods: (1) the escalation of opioid prescriptions for CNCP; (2) an interim period in which the efficacy of and risks associated with opioids were re-assessed; and (3) the current period of "opioid pharmacovigilance," characterized by the increased surveillance of opioid prescriptions. Clinicians reported that interpretations of the evidence-base in favor of and opposing opioid prescribing for CNCP evolved within a larger clinical-social context. Historically, pharmaceutical marketing efforts and clinicians' concerns about racialized healthcare disparities in pain treatment influenced opioid prescription decision-making. Clinicians emphasized how patients' medical complexity (e.g. multiple chronic health conditions) and structural vulnerability (e.g. poverty, community violence) impacted access to opioids within resource-limited healthcare settings. This clinical-social history of opioid prescribing practices helps to elucidate the ongoing challenges of CNCP treatment in the US healthcare safety net and lends needed specificity to the broader, nationwide conversation about opioids.

Indexed as

PharmacovigilanceAnalgesics, OpioidChronic PainHumansPain ManagementPractice Patterns, Physicians'Qualitative ResearchSubstance-Related DisordersAnalgesics, OpioidChronic non-cancer painOpioidsPharmacovigilancePovertyPrimary care safety netSocial medicineUnited States

Identifiers

PMID28599142
PMCPMC5551446

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.