Evidence map›Paper›PMID 28599054›Full record

ArticleThe British journal of dermatology2017

Coexistence of Eph receptor B1 and ephrin B2 in port-wine stain endothelial progenitor cells contributes to clinicopathological vasculature dilatation.

W Tan, J Wang, F Zhou, L Gao, R Yin, H Liu, A Sukanthanag, G Wang, M C Mihm, D-B Chen and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
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  10. Similarities and differences between brain and skinbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Capillary malformations.The Journal of clinical investigation · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

W TanDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.ORCID 0000-0002-2334-8988
J WangDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.
F ZhouDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.
L GaoDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.
R YinDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.ORCID 0000-0003-4653-3489
H LiuShandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, 250022, China.
A SukanthanagDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.
G WangDepartment of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
M C MihmDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, U.S.A.
D-B ChenDepartment of Obstetrics and Gynecology, University of California, Irvine, Irvine, CA, U.S.A.
J S NelsonDepartment of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, U.S.A.
University of California, Irvine · USCentral South University · CNBrigham and Women's Hospital · USShandong Provincial Institute of Dermatology and Venereology · CNShanxi Medical University · CNXijing Hospital · CN

Funding

Actions of Estrogen on Uterine Artery EndotheliumR01HL070562 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, DONGBAO · 2001 to 2025
$6.3M
Novel Approach to Improve Port Wine Stain Treatment in Human SkinR01AR059244 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NELSON, JOHN STUART · 2010 to 2012
$930k
Mid-Career Investigator in Patient-Oriented ResearchK24AR047551 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NELSON, JOHN STUART · 2003 to 2007
$655k
Molecular mechanisms of pulsed dye laser combined with topical rapamycin for portK01AR063766 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI TAN, WENBIN · 2013 to 2017
$444k
NHLBI NIH HHS R01 HL070562NIAMS NIH HHS K01 AR063766NIAMS NIH HHS K24 AR047551NIAMS NIH HHS R01 AR059244
6 · The paper itself

Abstract

backgroundPort-wine stain (PWS) is a vascular malformation characterized by progressive dilatation of postcapillary venules, but the molecular pathogenesis remains obscure.

objectivesTo illustrate that PWS endothelial cells (ECs) present a unique molecular phenotype that leads to pathoanatomical PWS vasculatures.

methodsImmunohistochemistry and transmission electron microscopy were used to characterize the ultrastructure and molecular phenotypes of PWS blood vessels. Primary culture of human dermal microvascular endothelial cells and in vitro tube formation assay were used for confirmative functional studies.

resultsMultiple clinicopathological features of PWS blood vessels during the development and progression of the disease were shown. There were no normal arterioles and venules observed phenotypically and morphologically in PWS skin; arterioles and venules both showed differentiation impairments, resulting in a reduction of arteriole-like vasculatures and defects in capillary loop formation in PWS lesions. PWS ECs showed stemness properties with expression of endothelial progenitor cell markers CD133 and CD166 in non-nodular lesions. They also expressed dual venous/arterial identities, Eph receptor B1 (EphB1) and ephrin B2 (EfnB2). Co-expression of EphB1 and EfnB2 in normal human dermal microvascular ECs led to the formation of PWS-like vasculatures in vitro, for example larger-diameter and thick-walled capillaries.

conclusionsPWS ECs are differentiation-impaired, late-stage endothelial progenitor cells with a specific phenotype of CD133

Indexed as

AdolescentAdultArteriolesCells, CulturedChildChild, PreschoolDilatation, PathologicEndothelial Progenitor CellsFemaleHumansInfantInfant, NewbornMaleMiddle AgedPort-Wine StainReceptor, EphB1Receptor, EphB1Receptor, EphB2

Identifiers

PMID28599054
PMCPMC9375175
OpenAlexW2621895512

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.