ArticlePloS one2017
Computational analysis of multimorbidity between asthma, eczema and rhinitis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 49 citations in OpenAlex.
- Self-reported respiratory allergic symptoms and eczema in schoolchildren in Peja region-west Kosovo.Scientific reports · 2026Article
- Maternal and perinatal outcomes of asthma exacerbation during pregnancy in a Chinese population: a retrospective cohort study.BMC pulmonary medicine · 2024Article
- Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight.Nature communications · 2024Article
- Correlation ofAsia Pacific allergy · 2024Article
- Distinction between rhinitis alone and rhinitis with asthma using interactomics.Scientific reports · 2023Article
- Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis.Scientific reports · 2022Article
- Real-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities.Clinical and translational allergy · 2022Article
- Current Insights on the Impact of Proteomics in Respiratory Allergies.International journal of molecular sciences · 2022Review
- Integrating Multimorbidity into a Whole-Body Understanding of Disease Using Spatial Genomics.Results and problems in cell differentiation · 2022Article
- Turkish Guideline for Diagnosis and Treatment of Allergic Rhinitis (ART).Turkish archives of otorhinolaryngology · 2021Article
- A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents.Allergy · 2020Article
- Comparison of individual-level and population-level risk factors for rhinoconjunctivitis, asthma, and eczema in the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three.The World Allergy Organization journal · 2020Article
- Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.BMC pediatrics · 2020Article
- Atopy and allergic diseases among Saudi young adults: A cross-sectional study.The Journal of international medical research · 2020Article
- Article
- Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma.Current allergy and asthma reports · 2018Review
- Relationship Between Rhinitis, Asthma, and Eczema and the Presence of Sensitization in Young Swiss Adults.Allergy & rhinology (Providence, R.I.)Article
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Authors and funding
25 authors at 17 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them.
methodsAn in silico study based on computational analysis of the topology of the protein interaction network was performed in order to characterize the molecular mechanisms of multimorbidity of asthma, eczema and rhinitis. As a first step, proteins associated to either disease were identified using data mining approaches, and their overlap was calculated. Secondly, a functional interaction network was built, allowing to identify cellular pathways involved in allergic multimorbidity. Finally, a network-based algorithm generated a ranked list of newly predicted multimorbidity-associated proteins.
resultsAsthma, eczema and rhinitis shared a larger number of associated proteins than expected by chance, and their associated proteins exhibited a significant degree of interconnectedness in the interaction network. There were 15 pathways involved in the multimorbidity of asthma, eczema and rhinitis, including IL4 signaling and GATA3-related pathways. A number of proteins potentially associated to these multimorbidity processes were also obtained.
conclusionsThese results strongly support the existence of an allergic multimorbidity cluster between asthma, eczema and rhinitis, and suggest that type 2 signaling pathways represent a relevant multimorbidity mechanism of allergic diseases. Furthermore, we identified new candidates contributing to multimorbidity that may assist in identifying new targets for multimorbid allergic diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.