SynthesisNature communications2017
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 8 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations.Nature communications · 2026Pooled it
- The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank.British journal of cancer · 2026Pooled it
- Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions.Nature genetics · 2024Pooled it
- Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2022Guideline
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Nature communications · 2021Pooled it
- Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Pooled it
- Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.Nature communications · 2018Pooled it
- Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.European urology · 2017Pooled it
- Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability.Cell reports · 2026Article
- HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma.Nature communications · 2026Article
- Elevated preoperative inflammatory ratios (NLR/PLR) predict adverse pathology and poor surgical outcomes in metastatic renal cell carcinoma: a retrospective analysis.American journal of translational research · 2026Article
- Validation ofFrontiers in medicine · 2026Article
- Integrative multi-omic analysis identifies key transcription factors and target proteins in renal cell carcinoma and its subtypes.bioRxiv : the preprint server for biology · 2025Article
- Quantification method affects replicability of eQTL analysis, colocalization, and TWAS.bioRxiv : the preprint server for biology · 2025Article
- Systematically identification of survival-associated eQTLs in a Japanese kidney cancer cohort.PLoS genetics · 2025Article
- Promoter Hyper-methylation of ZNF662 Restrains its Tumor Suppressing Function in Triple-Negative Breast Cancer Through Regulating NGF Signaling Axis.International journal of biological sciences · 2025Article
- Risk-based screening and prognostic analysis for second primary malignancies in kidney cancer patients: a retrospective cohort study based on large-scale population and Mendelian randomization analysis.International journal of medical sciences · 2025Article
- Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma.American journal of human genetics · 2024Article
- Plasma Kidney Injury Molecule-1 for Preoperative Prediction of Renal Cell Carcinoma Versus Benign Renal Masses, and Association With Clinical Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Integrating muti-omics data to identify tissue-specific DNA methylation biomarkers for cancer risk.Nature communications · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
123 authors at 20 institutions in 19 countries.
Ghislaine SceloInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Mattias JohanssonInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Zhaoming WangDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Jeanette E Eckel-PassowDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Yuanqing YeDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Jiyeon ChoiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Matthieu FollInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Valerie GaborieauInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.ORCID 0000-0001-6538-9705
Leandro M ColliDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Peng LiInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Joshua N SampsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Behnoush Abedi-ArdekaniInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Celine BesseCentre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives, 91057 Evry, France.
Helene BlancheFondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, 75010 Paris, France.
Anne BolandCentre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives, 91057 Evry, France.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Amelie ChabrierInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Geoffroy DurandInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Florence Le Calvez-KelmInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Egor ProkhortchoukCenter 'Bioengineering' of the Russian Academy of Sciences, Moscow 117312, Russia.
Nivonirina RobinotInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Konstantin G SkryabinCenter 'Bioengineering' of the Russian Academy of Sciences, Moscow 117312, Russia.
Magdalena B WozniakInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Gordana Basta-JovanovicInstitute of Pathology, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Zoran DzamicClinical Center of Serbia (KCS), Clinic of Urology, University of Belgrade-Faculty of Medicine, 11000 Belgrade, Serbia.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Ivana Holcatova2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, 150 06 Prague 5, Czech Republic.
Vladimir JanoutDepartment of Preventive Medicine, Faculty of Medicine, Palacky University, 775 15 Olomouc, Czech Republic.
Dana MatesNational Institute of Public Health, 050463 Bucharest, Romania.
Anush MukeriyaRussian N.N. Blokhin Cancer Research Centre, Moscow 115478, Russian Federation.
Stefan RascuCarol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, 050659 Bucharest, Romania.
David ZaridzeRussian N.N. Blokhin Cancer Research Centre, Moscow 115478, Russian Federation.
Vladimir BenckoFirst Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, 128 00 Prague 2, Czech Republic.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-204 Szczecin, Poland.
Eleonora FabianovaRegional Authority of Public Health in Banska Bystrica, 975 56 Banska Bystrica, Slovakia.
Viorel JingaCarol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, 050659 Bucharest, Romania.
Jolanta LissowskaThe M Sklodowska-Curie Cancer Center and Institute of Oncology, 02-034 Warsaw, Poland.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-204 Szczecin, Poland.
Marie NavratilovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic.
Peter RudnaiNational Public Health Center, National Directorate of Environmental Health, 1097 Budapest, Hungary.
Neonila Szeszenia-DabrowskaDepartment of Epidemiology, Institute of Occupational Medicine, 91-348 Lodz, Poland.
Simone BenhamouUniversité Paris Diderot, INSERM, Unité Variabilité Génétique et Maladies Humaines, 75010 Paris, France.
Geraldine Cancel-TassinCeRePP, Tenon Hospital, 75020 Paris, France.
Olivier CussenotCeRePP, Tenon Hospital, 75020 Paris, France.
Laura BagliettoCentre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy, 94805 Villejuif, France.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, 14558 Nuthetal, Germany.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0QQ, UK.
Elisabete WeiderpassDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway.
Borje LjungbergDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85 Umeå, Sweden.
Raviprakash T SitaramDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85 Umeå, Sweden.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Susan J JordanQIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia.
Gianluca SeveriCentre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy, 94805 Villejuif, France.
Ingrid WinshipDepartment of Medicine, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway.
Lars J VattenDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Tony FletcherLondon School of Hygiene and Tropical Medicine, University of London, London WC1H 9SH, UK.
Kvetoslava KoppovaRegional Authority of Public Health in Banska Bystrica, 975 56 Banska Bystrica, Slovakia.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0003-0118-0341
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0001-7387-6845
Rosamonde E BanksLeeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds LS9 7TF, UK.
Peter J SelbyLeeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds LS9 7TF, UK.
Douglas F EastonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0QQ, UK.
Paul PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-8494-732X
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Satu MännistöDepartment of Health, National Institute for Health and Welfare, 00271 Helsinki, Finland.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Peter E ClarkVanderbilt-Ingram Cancer Center, Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Todd L EdwardsVanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37209, USA.ORCID 0000-0003-4318-6119
Loren LipworthVanderbilt-Ingram Cancer Center, Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
Susan M GapsturAmerican Cancer Society, Atlanta, Georgia 30303, USA.
Victoria L StevensAmerican Cancer Society, Atlanta, Georgia 30303, USA.
Hallie CarolDana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Matthew L FreedmanDana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Mark M PomerantzDana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Eunyoung ChoWarren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.
Peter KraftHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Mark A PrestonBrigham and Women's Hospital and VA Boston, Boston, Massachusetts 02115, USA.
Kathryn M WilsonHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
J Michael GazianoBrigham and Women's Hospital and VA Boston, Boston, Massachusetts 02115, USA.
Howard D SessoHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Amanda BlackDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
John G AnemaDivision of Urology, Spectrum Health, Grand Rapids, Michigan 49503, USA.
Richard J KahnoskiDivision of Urology, Spectrum Health, Grand Rapids, Michigan 49503, USA.
Brian R LaneDivision of Urology, Spectrum Health, Grand Rapids, Michigan 49503, USA.
Sabrina L NoyesVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, Michigan 49503, USA.
David PetilloVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, Michigan 49503, USA.
Bin Tean TehVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, Michigan 49503, USA.
Ulrike PetersCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Emily WhiteCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Garnet L AndersonCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Lisa JohnsonCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, Indiana 47405, USA.
Julie BuringHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
I-Min LeeHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Wong-Ho ChowDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.
Lee E MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Christopher WoodDepartment of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Timothy EisenDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
Marc HenrionDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
James LarkinMedical Oncology, Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
Poulami BarmanDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Bradley C LeibovichDepartment of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55902, USA.
Toni K ChoueiriDana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
G Mark LathropMcGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada H3A 0G1.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
Jean-Francois DeleuzeCentre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives, 91057 Evry, France.
James D McKayInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Alexander S ParkerDepartment of Health Sciences Research, Mayo Clinic, Jacksonville, Florida 32224, USA.
Xifeng WuDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230, USA.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
Paul BrennanInternational Agency for Research on Cancer (IARC), 69008 Lyon, France.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.
National Institutes of Health · USCentre international de recherche sur le cancer · FRBrigham and Women's Hospital · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USThe University of Texas MD Anderson Cancer Center · USCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRKarolinska Institutet · SEUniversity of Cambridge · GBVan Andel Institute · USAmerican Cancer Society · USCarol Davila University of Medicine and Pharmacy · ROCharles University · CZHarvard University · USInternational Hereditary Cancer Center · PLMasaryk Memorial Cancer Institute · CZMayo Clinic in Florida · USNorwegian University of Science and Technology · NOPublic Health Authority of the Slovak Republic · SK
Funding
Pooled genome-wide analysis of kidney cancer riskU01CA155309 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI SCELO, GHISLAINE · 2011 to 2014
$3.7MCancer Research UK 10124Cancer Research UK 14136Cancer Research UK 16561Cancer Research UK 6858Department of Health RP-PG-0707-10101Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/N003284/1NCI NIH HHS U01 CA155309World Health Organization 001
Abstract
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAdolescentAdultAgedCarcinoma, Renal CellFemaleGenetic LociGerm-Line MutationHumansKidney NeoplasmsMaleMiddle AgedPhenotypePolymorphism, Single NucleotideWhite People
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.