ArticleNature communications2017
Refinement of learned skilled movement representation in motor cortex deep output layer.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
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- The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements.iScience · 2026Article
- Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task-related Neuronal Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Motor imagery enhances performance beyond the imagined action.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning.iScience · 2024Article
- Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders.Molecular psychiatry · 2024Article
- Noninvasive Deep Brain Stimulation via Temporal Interference Electric Fields Enhanced Motor Performance of Mice and Its Neuroplasticity Mechanisms.Molecular neurobiology · 2024Article
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Article
- Endogenous dopamine transmission is crucial for motor skill recovery after stroke.IBRO neuroscience reports · 2022Article
- Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement.Neuron · 2022Article
- Transition from predictable to variable motor cortex and striatal ensemble patterning during behavioral exploration.Nature communications · 2022Article
- Corticospinal neurons from motor and somatosensory cortices exhibit different temporal activity dynamics during motor learning.Frontiers in human neuroscience · 2022Article
- Collapse of complexity of brain and body activity due to excessive inhibition and MeCP2 disruption.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the emergence of learned motor skill representation in primary motor cortex (M1) are not well understood. Specifically, how motor representation in the deep output layer 5b (L5b) is shaped by motor learning remains virtually unknown. In rats undergoing motor skill training, we detect a subpopulation of task-recruited L5b neurons that not only become more movement-encoding, but their activities are also more structured and temporally aligned to motor execution with a timescale of refinement in tens-of-milliseconds. Field potentials evoked at L5b in vivo exhibit persistent long-term potentiation (LTP) that parallels motor performance. Intracortical dopamine denervation impairs motor learning, and disrupts the LTP profile as well as the emergent neurodynamical properties of task-recruited L5b neurons. Thus, dopamine-dependent recruitment of L5b neuronal ensembles via synaptic reorganization may allow the motor cortex to generate more temporally structured, movement-encoding output signal from M1 to downstream circuitry that drives increased uniformity and precision of movement during motor learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.