ArticleNature communications2017
Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth.
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Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Structural Control of Stromal-Immune Coupling by COL24A1 Underlies Pregnancy Maintenance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Infancy IgE methylation score and childhood wheezing and asthma: Multicohort study.The Journal of allergy and clinical immunology · 2026Article
- Placental biology links genetic, epigenetic, ancestral, and social determinants to maternal-fetal health inequities.Frontiers in reproductive health · 2026Review
- Molecular profiles of the great obstetrical syndromes reveal common features and dynamic changes in early pregnancy.Communications medicine · 2025Article
- Mapping genetic susceptibility to spontaneous preterm birth: analysis of Utah pedigrees to find inherited genetic factors.American journal of obstetrics and gynecology · 2025Article
- Association of maternal prenatal phthalate exposure and genetic polymorphisms of metabolic enzyme genes with spontaneous preterm birth: a nested case-control study in China.BMC pregnancy and childbirth · 2025Article
- Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.BMC medicine · 2024Article
- Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.Clinics in perinatology · 2024Review
- A Scoping Review of Preterm Birth Risk Factors.American journal of perinatology · 2024Article
- Review
- Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth.Science advances · 2024Article
- Genetic association study of Preterm birth and Gestational age in a population-based case-control study in Peru: Genetics of PTB and GA in pregnant women in Peru.medRxiv : the preprint server for health sciences · 2023Article
- Maternal pre-pregnancy BMI, offspring epigenome-wide DNA methylation, and childhood obesity: findings from the Boston Birth Cohort.BMC medicine · 2023Article
- Microdiversity of the vaginal microbiome is associated with preterm birth.Nature communications · 2023Article
- Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth.bioRxiv : the preprint server for biology · 2023Article
- Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence.EBioMedicine · 2023Article
- Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator.Clinical epigenetics · 2023Article
- Genetics, epigenetics, and transcriptomics of preterm birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Review
- Boston Birth Cohort profile: rationale and study design.Precision nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 9 institutions in 3 countries.
Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Hongkai JiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health Baltimore, Maryland 21205, USA.
Shouneng PengDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Ben SherwoodDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health Baltimore, Maryland 21205, USA.
Antonio Di NarzoDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Hui-Ju TsaiDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Xin LiuDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Irina BurdIntegrated Research Center for Fetal Medicine, Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Yuelong JiCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Deanna CarusoCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Guangyun MaoCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Tami R BartellMary Ann &J. Milburn Smith Child Health Research Program, Stanley Manne Children's Research Institute, Ann &Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.
Zhongyang ZhangDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Colleen PearsonDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA.
Linda HeffnerDepartment of Obstetrics and Gynecology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Sandra CerdaDepartment of Pathology and Laboratory Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Terri H BeatyDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
M Daniele FallinDepartment of Mental Health, Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Aviva Lee-ParritzDepartment of Obstetrics and Gynecology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Barry ZuckermanDepartment of Pediatrics, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA.
Daniel E WeeksDepartment of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Johns Hopkins University · USIcahn School of Medicine at Mount Sinai · USBoston University · USBoston Medical Center · USJohns Hopkins Medicine · USLurie Children's Hospital · USNational Health Research Institutes · TWNorthwestern University · USUniversity of Pittsburgh · US
Funding
Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1MResearch Infrastructure for the Hopkins Population CenterR24HD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHERLIN, ANDREW J · 2003 to 2017
$5.1MMolecular Epidemiology of Preterm BirthR21ES011666 · NIEHS · CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) · PI WANG, XIAOBIN · 2002 to 2004
$562kEpigenome-wide Association Study of Preterm BirthR21HD066471 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$354kNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INICHD NIH HHS R01 HD041702NICHD NIH HHS R21 HD066471NICHD NIH HHS R24 HD042854NIEHS NIH HHS R21 ES011666
Abstract
Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such 'missing heritability' may be partly due to gene × environment interactions (G × E), which is largely unexplored. Here we conduct genome-wide G × E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston Birth Cohort. We show that maternal COL24A1 variants have a significant genome-wide interaction with maternal pre-pregnancy overweight/obesity on PTB risk, with rs11161721 (P
Indexed as
Gene-Environment InteractionAdultBlack or African AmericanBody Mass IndexFemaleGenetic Predisposition to DiseaseHumansInfant, NewbornNon-Fibrillar CollagensObesityPolymorphism, Single NucleotidePregnancyPremature BirthRisk FactorsYoung AdultCOL25A1 protein, humanNon-Fibrillar Collagens
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