Evidence map›Paper›PMID 28598389›Full record

ArticleMarine drugs2017

Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor.

Shantong Jiang, Han-Shen Tae, Shaoqiong Xu, Xiaoxia Shao, David J Adams, Chunguang Wang

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Shantong JiangDepartment of Central Laboratory, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. jajst2010@163.com.
Han-Shen TaeIllawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW 2522, Australia. hstae@uow.edu.au.
Shaoqiong XuDepartment of Central Laboratory, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. xsq1201@163.com.
Xiaoxia ShaoDepartment of Central Laboratory, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. shxx@tongji.edu.cn.
David J AdamsIllawarra Health and Medical Research Institute (IHMRI), University of Wollongong, Wollongong, NSW 2522, Australia. djadams@uow.edu.au.
Chunguang WangDepartment of Central Laboratory, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. chunguangwang@tongji.edu.cn.
Tongji University · CNUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conotoxins are a pool of disulfide-rich peptide neurotoxins produced by cone snails for predation and defense. They are a rich reservoir of novel ligands for ion channels, neurotransmitter receptors and transporters in the nervous system. In this study, we identified a novel conotoxin component, O-conotoxin GeXXVIIA, from the venom of

Indexed as

Amino Acid SequenceAnimalsBase SequenceConotoxinsConus SnailHumansNeurotoxinsNicotinic AntagonistsOocytesPeptidesReceptors, NicotinicXenopus laevisConotoxinsNeurotoxinsNicotinic AntagonistsPeptidesReceptors, Nicotinicconotoxinlinear peptidenicotinic receptorO-superfamilyα9α10

Identifiers

PMID28598389
PMCPMC5484120
OpenAlexW2622155979

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.