Evidence map›Paper›PMID 28598384›Full record

ArticleMolecules (Basel, Switzerland)2017

Anti-Inflammatory and Neuroprotective Constituents from the Peels of Citrus grandis.

Ping-Chung Kuo, Yu-Ren Liao, Hsin-Yi Hung, Chia-Wei Chuang, Tsong-Long Hwang, Shiow-Chyn Huang, Young-Ji Shiao, Daih-Huang Kuo, Tian-Shung Wu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Effects ofJournal of Zhejiang University. Science. B · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Neurotrophic Natural Products.Progress in the chemistry of organic natural products · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Flavonoids as inhibitors of human neutrophil elastase.Journal of enzyme inhibition and medicinal chemistry · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Neuroprotective and Neurorestorative Effects ofFrontiers in neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ping-Chung KuoSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10502016@email.ncku.edu.tw.
Yu-Ren LiaoSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. truthloveroy@yahoo.com.tw.
Hsin-Yi HungSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10308005@email.ncku.edu.tw.
Chia-Wei ChuangDepartment of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. w96s062001@hotmail.com.
Tsong-Long HwangGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
Shiow-Chyn HuangDepartment of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan. schuang@mail.cnu.edu.tw.
Young-Ji ShiaoDivision of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan. yshiao@nricm.edu.tw.
Daih-Huang KuoDepartment of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. dhkou@tajen.edu.tw.
Tian-Shung WuSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw.
National Cheng Kung University · TWTajen University · TWChang Gung University of Science and Technology · TWChia Nan University of Pharmacy and Science · TWNational Research Institute of Chinese Medicine · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (

Indexed as

Amyloid beta-PeptidesAnimalsAnti-Inflammatory AgentsCell DeathCerebral CortexCitrusComplex MixturesCoumarinsFlavonoidsFruitHumansLeukocyte ElastaseLignansNeuronsNeuroprotective AgentsNeutrophilsAmyloid beta-Peptidesamyloid beta-protein (25-35)Anti-Inflammatory AgentsComplex MixturesCoumarinsFlavonoidsLeukocyte ElastaseLignansNeuroprotective AgentsPeptide FragmentsSteroidsSuperoxidesTriterpenesWaste Productschromatographic methodCitrus grandiselastase releaseneuroprotectivespectroscopic elucidationsuperoxide anion generation

Identifiers

PMID28598384
PMCPMC6152662
OpenAlexW2622546133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.