Evidence map›Paper›PMID 28598328›Full record

ArticleeLife2017

A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses.

Matthew D Pauly, Megan C Procario, Adam S Lauring

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Mutation rate variability in viral populations: Implications for lethal mutagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Matthew D PaulyDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, United States.
Megan C ProcarioDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, United States.
Adam S LauringDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, United States.ORCID 0000-0003-2906-8335

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Fidelity, robustness, and diversity in RNA virus evolution and pathogenesisR01AI118886 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM · 2016 to 2020
$2.0M
Doris Duke Charitable Foundation 2013105NIAID NIH HHS R01 AI118886NIGMS NIH HHS T32 GM007544
6 · The paper itself

Abstract

Influenza virus' low replicative fidelity contributes to its capacity for rapid evolution. Clonal sequencing and fluctuation tests have suggested that the influenza virus mutation rate is 2.7 × 10

Indexed as

Mutation RateAnimalsDogsFluorometryGenes, ReporterGreen Fluorescent ProteinsHEK293 CellsHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMadin Darby Canine Kidney CellsMolecular BiologyVirologyGreen Fluorescent Proteinsdiversityevolutionevolutionary biologygenomicsinfectious diseasemicrobiologymutation ratevirus

Identifiers

PMID28598328
PMCPMC5511008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.