Evidence map›Paper›PMID 28598289›Full record

ArticleRadiation research2017

Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.

Chen-Ting Lee, Yingchun Zhou, Kingshuk Roy-Choudhury, Sharareh Siamakpour-Reihani, Kenneth Young, Peter Hoang, John P Kirkpatrick, Jen-Tsan Chi, Mark W Dewhirst, Janet K Horton

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Early Radiation Therapy Response Assessment Using Multi-Scale Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. The British journal of radiology · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chen-Ting LeeDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Yingchun ZhouDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Kingshuk Roy-Choudhuryb   Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina.
Sharareh Siamakpour-ReihaniDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Kenneth YoungDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Peter HoangDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
John P KirkpatrickDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Jen-Tsan Chic   Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina.
Mark W DewhirstDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Janet K HortonDepartment of a   Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Duke Medical Center · US

Funding

Interdisciplinary Research Careers in Women's HealthK12HD043446 · NICHD · DUKE UNIVERSITY · PI AMUNDSEN, CINDY · 2002 to 2023
$9.6M
NCI NIH HHS L30 CA142414NICHD NIH HHS K12 HD043446
6 · The paper itself

Abstract

Breast cancer is the most common malignancy diagnosed among women and represents a heterogeneous group of subtypes. Radiation therapy is a critical component of treatment for breast cancer patients. However, little is known about radiation response among these intrinsic subtypes. In previous studies, we identified a significant induction of FAS after irradiation in biologically favorable breast cancer patients and breast cancer cell lines. Here, we expanded our study and investigated radiation response in a mouse model of breast cancer. MCF7 (luminal), HCC1954 (HER2

Indexed as

AnimalsBreast NeoplasmsCell Line, TumorCell Transformation, NeoplasticFas Ligand Proteinfas ReceptorFemaleGene Expression Regulation, NeoplasticGene SilencingHumansMiceRadiation ToleranceTreatment OutcomeFas Ligand Proteinfas Receptor

Identifiers

PMID28598289
PMCPMC5816985
OpenAlexW2623093746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.