Evidence map›Paper›PMID 28598268›Full record

ArticleJournal of toxicology and environmental health. Part A2017

Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity.

K Krajnak, K Sriram, C Johnson, J R Roberts, R Mercer, G R Miller, O Wirth, J M Antonini

Abstract read
In one paragraph

Article in Journal of toxicology and environmental health. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Health effects associated with occupational exposure to hand-arm or whole body vibration.Journal of toxicology and environmental health. Part B, Critical reviews · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

K Krajnaka Engineering Controls and Technology Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA.
K Sriramb Toxicology and Molecular Biology Branch , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
C Johnsona Engineering Controls and Technology Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA.
J R Robertsc Exposure Assessment Branch , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
R Mercerd Physiology and Pathology Research Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA.
G R Millera Engineering Controls and Technology Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA.
O Wirthe Biostatistic and Epidemiology Branch , National Institute for Occupational Safety and Health , Morgantown , WV , USA.
J M Antoninid Physiology and Pathology Research Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA.
National Institute for Occupational Safety and Health · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Exposure to welding fumes may result in disorders of the pulmonary, cardiovascular, and reproductive systems. Welders are also at a greater risk of developing symptoms similar to those seen in individuals with idiopathic Parkinson's disease. In welders, there are studies that suggest that alterations in circulating prolactin concentrations may be indicative of injury to the dopamine (DA) neurons in the substantia nigra. The goal of these studies was to use an established model of welding particulate exposure to mimic the effects of welding fume inhalation on reproductive functions. Since previous investigators suggested that changes in circulating prolactin may be an early marker of DA neuron injury, movement disorders, and reproductive dysfunction, prolactin, hypothalamic tyrosine hydroxylase (TH) levels (a marker of DA synthesis), and other measures of hypothalamic-pituitary-gonadal (HPG) function were measured after repetitive instillation of welding fume particulates generated by flux core arc-hard surfacing (FCA-HS), manual metal arc-hard surfacing (MMA-HS) or gas metal arc-mild steel (GMA-MS) welding, or manganese chloride (MnCl

Indexed as

Inhalation ExposureOccupational ExposureWeldingAir Pollutants, OccupationalAnimalsBiomarkersChloridesHypothalamusMaleManganeseManganese CompoundsParkinson Disease, SecondaryProlactinRatsRats, Sprague-DawleyReproductionAir Pollutants, OccupationalBiomarkersChloridesManganesemanganese chlorideManganese CompoundsProlactinTestosteroneTyrosine 3-Monooxygenase

Identifiers

PMID28598268
PMCPMC6422021
OpenAlexW2622579667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.