Evidence map›Paper›PMID 28597820›Full record

ReviewMicrobiology spectrum2017

Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.

Gregory M Cook, Kiel Hards, Elyse Dunn, Adam Heikal, Yoshio Nakatani, Chris Greening, Dean C Crick, Fabio L Fontes, Kevin Pethe, Erik Hasenoehrl and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 127 citations in OpenAlex.

  1. Dual inhibition of respiratory complexes inMicrobiology spectrum · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. New Triazolopyrimidines with Improved Activity againstACS medicinal chemistry letters · 2025
    Article
  11. Efficacy of novel regimens targeting oxidative phosphorylation inAntimicrobial agents and chemotherapy · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. CytochromeRSC medicinal chemistry · 2024
    Review
  20. Metabolic Rewiring ofMetabolites · 2024
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Gregory M CookUniversity of Otago, Department of Microbiology and Immunology, Otago School of Medical Sciences, Dunedin, New Zealand.
Kiel HardsUniversity of Otago, Department of Microbiology and Immunology, Otago School of Medical Sciences, Dunedin, New Zealand.
Elyse DunnUniversity of Otago, Department of Microbiology and Immunology, Otago School of Medical Sciences, Dunedin, New Zealand.
Adam HeikalUniversity of Otago, Department of Microbiology and Immunology, Otago School of Medical Sciences, Dunedin, New Zealand.
Yoshio NakataniUniversity of Otago, Department of Microbiology and Immunology, Otago School of Medical Sciences, Dunedin, New Zealand.
Chris GreeningThe Commonwealth Scientific and Industrial Research Organization, Land and Water Flagship, Acton ACT, Australia.
Dean C CrickColorado State University, Department of Microbiology, Immunology, and Pathology, Fort Collins, CO 80523.
Fabio L FontesColorado State University, Department of Microbiology, Immunology, and Pathology, Fort Collins, CO 80523.
Kevin PetheLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Erik HasenoehrlAlbert Einstein School of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461.
Michael BerneyAlbert Einstein School of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461.
University of Otago · NZAlbert Einstein College of Medicine · USColorado State University · USMaurice Wilkins Centre · NZMonash University · AUNanyang Technological University · SGUniversity of Auckland · NZ

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Sterol/Hopanoid Biosynthesis: An Anti-TB Drug TargetR01AI049151 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI CRICK, DEAN C · 2001 to 2019
$4.1M
Inhibition of methionine biosynthesis eliminates persistent M. tuberculosis.R21AI119573 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERNEY, MICHAEL · 2016 to 2017
$459k
Menaquinone biosynthesis: a drug target in Gram-positive bacteriaR56AI049151 · NIAID · COLORADO STATE UNIVERSITY · PI CRICK, DEAN C · 2007 to 2007
$320k
Targeting terminal respiratory oxidation in Mycobacterium tuberculosis: A novel investigation of Cytochrome bd oxidase functionF30AI138483 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HASENOEHRL, ERIK · 2018 to 2018
$50k
NIAID NIH HHS F30 AI138483NIAID NIH HHS R01 AI049151NIAID NIH HHS R21 AI119573NIAID NIH HHS R56 AI049151NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

The emergence and spread of drug-resistant pathogens, and our inability to develop new antimicrobials to combat resistance, have inspired scientists to seek out new targets for drug development. The

Indexed as

Antitubercular AgentsDrug DiscoveryDrug Resistance, BacterialEnergy MetabolismMycobacterium tuberculosisOxidative PhosphorylationOxidoreductasesTuberculosisAntitubercular AgentsOxidoreductases

Identifiers

PMID28597820
PMCPMC5480969
OpenAlexW2622825521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.