ReviewMicrobiology spectrum2017
Microbial Impact on Host Metabolism: Opportunities for Novel Treatments of Nutritional Disorders?
Review in Microbiology spectrum, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The metabolic endotoxemia and gut microbiota: research trajectories and hot trends across the centuries (1999-2024).Frontiers in microbiology · 2025Pooled it
- Effects of exercise and physical activity on gut microbiota composition and function in older adults: a systematic review.BMC geriatrics · 2023Pooled it
- Association between physical activity and changes in intestinal microbiota composition: A systematic review.PloS one · 2021Pooled it
- Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials.Nutrients · 2020Pooled it
- Periodontitis-associated gut microbiota disrupts glucose homeostasis through SCFAs depletion and inflammation in germ-free mice.BMC oral health · 2026Article
- Comparison of the fecal microbiota with high- and low performance race horses.Journal of animal science and technology · 2024Article
- Metabolic syndrome therapy in pediatric age - between classic and modern. From diets to pipeline drugs.Frontiers in nutrition · 2024Review
- Indoleacrylic acid produced by Parabacteroides distasonis alleviates type 2 diabetes via activation of AhR to repair intestinal barrier.BMC biology · 2023Article
- Review
- Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence ofMicroorganisms · 2021Review
- Article
- Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation.Nutrients · 2020Review
- Rhubarb Supplementation Prevents Diet-Induced Obesity and Diabetes in Association with IncreasedNutrients · 2020Article
- The Role of Dysfunctional Adipose Tissue in Pancreatic Cancer: A Molecular Perspective.Cancers · 2020Review
- Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment.Nutrients · 2020Review
- Nutraceuticals as modulators of gut microbiota: Role in therapy.British journal of pharmacology · 2020Review
- Targeting Carbohydrates and Polyphenols for a Healthy Microbiome and Healthy Weight.Current nutrition reports · 2019Review
- Increases in Colonic Bacterial Diversity after ω-3 Fatty Acid Supplementation Predict Decreased Colonic Prostaglandin E2 Concentrations in Healthy Adults.The Journal of nutrition · 2019Article
- Acetate metabolic requirement of avian pathogenic Escherichia coli promotes its intracellular proliferation within macrophage.Veterinary research · 2019Article
- Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics.European journal of nutrition · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malnutrition is the cause of major public health concerns worldwide. On the one hand, obesity and associated pathologies (also known as the metabolic syndrome) affect more than 10% of the world population. Such pathologies might arise from an elevated inflammatory tone. We have discovered that the inflammatory properties of high-fat diets were linked to the translocation of lipopolysaccharide (LPS). We proposed a mechanism associating the gut microbiota with the onset of insulin resistance and low-grade inflammation, a phenomenon that we called "metabolic endotoxemia." We and others have shown that bacteria as well as host-derived immune-related elements control microbial communities and eventually contribute to the phenotype observed during diet-induced obesity, diabetes, and metabolic inflammation. On the other hand, undernutrition is one of the leading causes of death in children. A diet poor in energy and/or nutrients causes incomplete development of the gut microbiota and may profoundly affect energy absorption, initiating stunted growth, edema, and diarrhea. In this review, we discuss how changes in microbiota composition are associated with obesity and undernutrition. We also highlight that opposite consequences exist in terms of energy absorption from the diet (obesity versus undernutrition), but interestingly the two situations share similar defects in term of diversity, functionality, and inflammatory potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.