Evidence map›Paper›PMID 28597552›Full record

ArticleImmunity, inflammation and disease2017

Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice.

Bharathi Krishnan, Chandirasegaran Massilamany, Rakesh H Basavalingappa, Arunakumar Gangaplara, Guobin Kang, Qingsheng Li, Francisco A Uzal, Jennifer L Strande, Gustavo A Delhon, Jean-Jack Riethoven and 2 more

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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  12. β1-Adrenergic Receptor Contains Multiple IAFrontiers in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Bharathi KrishnanSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Chandirasegaran MassilamanySchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Rakesh H BasavalingappaSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Arunakumar GangaplaraSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Guobin KangNebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Qingsheng LiNebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Francisco A UzalSchool of Veterinary Medicine, University of California, Davis, California, USA.
Jennifer L StrandeDepartment of Medicine, Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Gustavo A DelhonSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Jean-Jack RiethovenCenter for Biotechnology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
David SteffenSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Jay ReddySchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0003-4082-9254
University of Nebraska–Lincoln · USMedical College of Wisconsin · USUniversity of California, Davis · US

Funding

Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
Autoimmunity in the Mediation of Infectious MyocarditisR01HL114669 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI REDDY, JAY · 2013 to 2016
$1.4M
NHLBI NIH HHS R01 HL114669NIGMS NIH HHS P30 GM103509
6 · The paper itself

Abstract

introductionOrgan-specific autoimmune diseases are believed to result from immune responses generated against self-antigens specific to each organ. However, when such responses target antigens expressed promiscuously in multiple tissues, then the immune-mediated damage may be wide spread.

methodsIn this report, we describe a mitochondrial protein, branched chain α-ketoacid dehydrogenase kinase (BCKD

resultsWe demonstrate that BCKD

conclusionsThe disease induced by BCKD

Indexed as

Amino Acid SequenceAnimalsAutoantigensAutoimmune DiseasesBiopsyCytokinesDisease Models, AnimalEpitopes, T-LymphocyteHepatitis, AutoimmuneHistocompatibility Antigens Class IIImmunizationMiceMyocarditisPeptide FragmentsProtein KinasesProtein Multimerization(3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinaseAutoantigensCytokinesEpitopes, T-LymphocyteHistocompatibility Antigens Class IIPeptide FragmentsProtein KinasesAutoimmune hepatitisautoimmune myocarditisautoreactive T cellsbranched chain α-ketoacid dehydrogenase kinasemouse model

Identifiers

PMID28597552
PMCPMC5691315
OpenAlexW2624487125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.