ArticleDigestive diseases and sciences2017
Microscopic Colitis Evolved Into Inflammatory Bowel Diseases Is Characterized by Increased Th1/Tc1 Cells in Colonic Mucosal Lamina Propria.
Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Microscopic colitis is associated with an increased risk of dementia in a Swedish population.Journal of internal medicine · 2026Article
- Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research.United European gastroenterology journal · 2025Review
- Inflammatory eye disease is a risk factor for future microscopic colitis: A nationwide population-based matched case control study.United European gastroenterology journal · 2024Article
- Lymphocytic colitis can be transcriptionally divided into channelopathic and inflammatory lymphocytic colitis.United European gastroenterology journal · 2024Article
- Insights into the underlying mechanisms and clinical management of microscopic colitis in relation to other gastrointestinal disorders.Gastroenterology report · 2022Review
- Macroscopic to Microscopic - A Case of Crohn's Disease Progressing to Collagenous Colitis.Cureus · 2021Article
- Case Report: Regulatory T Cell-Independent Induction of Remission in a Patient With Collagenous Colitis.Frontiers in medicine · 2021Article
- Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis?Digestive diseases and sciences · 2017Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn association between microscopic colitis (MC), i.e., lymphocytic colitis (LC) and collagenous colitis (CC), and inflammatory bowel diseases (IBD) has been noticed. A subset of MC cases may evolve into IBD, and IBD in remission may present as MC in a histologic pattern. Moreover, MC and IBD may coexist in different regions of the bowel. A link between MC and IBD in their pathogenesis is, therefore, suggested. Abnormal mucosal immunity is likely the key.
methodsWe reviewed 2324 MC cases in Calgary over 14 years and identified 20 cases evolved into IBD (IBD transformers). 13 of them were further investigated for colonic mucosal lamina propria mononuclear cells (LPMNCs), as opposed to 22 cases whose MC resolved. On their index colonic biopsy immunohistochemistry was performed to detect major T cell subsets characterized by key cytokines and master transcription factors (IFNγ and T-bet for Th1/Tc1, GATA-3 for Th2/Tc2, IL-17 and RORc for Th17/Tc17, FoxP3 for Treg/Tcreg) as well as TNFα
resultsIBD transformers had increased IFNγ
conclusionTh1/Tc1- and TNFα-producing cells, and likely a subset of Th2/Tc2 cells as well, may be involved in the MC-to-IBD transformation.
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Registered trials
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