ArticleCurrent opinion in systems biology2017
Global variation in gene expression and the value of diverse sampling.
Article in Current opinion in systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- α-Thalassemia has no association with asymptomatic Plasmodium falciparum carriage in three ecological zones of Ghana.Scientific reports · 2026Article
- Review
- The influence of genetics on the endocannabinoid system gene expression and relevance for targeting reproductive conditions.Journal of cannabis research · 2025Article
- Transferability of Single- and Cross-Tissue Transcriptome Imputation Models Across Ancestry Groups.Genetic epidemiology · 2025Article
- Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness.Computational and structural biotechnology journal · 2024Article
- Sex-biased gene regulation varies across human populations as a result of adaptive evolution.American journal of biological anthropology · 2024Article
- Transcriptomics and chromatin accessibility in multiple African population samples.bioRxiv : the preprint server for biology · 2023Article
- The genetic and evolutionary basis of gene expression variation in East Africans.Genome biology · 2023Article
- Advances in integrative African genomics.Trends in genetics : TIG · 2022Review
- Predictions, Pivots, and a Pandemic: a Review of 2020's Top Translational Bioinformatics Publications.Yearbook of medical informatics · 2021Review
- The influence of evolutionary history on human health and disease.Nature reviews. Genetics · 2021Review
- Genetic Architecture of Gene Expression in European and African Americans: An eQTL Mapping Study in GENOA.American journal of human genetics · 2020Article
- Bayesian Framework for Detecting Gene Expression Outliers in Individual Samples.JCO clinical cancer informatics · 2020Article
- Transcriptome variation in human populations and its potential application in forensics.Journal of applied genetics · 2019Review
- Inferred divergent gene regulation in archaic hominins reveals potential phenotypic differences.Nature ecology & evolution · 2019Article
- Genomics of disease risk in globally diverse populations.Nature reviews. Genetics · 2019Review
- PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects.Bioinformatics (Oxford, England) · 2019Article
- Sequence and Evolutionary Features for the Alternatively Spliced Exons of Eukaryotic Genes.International journal of molecular sciences · 2019Review
- Accuracy of Gene Expression Prediction From Genotype Data With PrediXcan Varies Across and Within Continental Populations.Frontiers in genetics · 2019Article
- Genetic architecture of gene expression traits across diverse populations.PLoS genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The genomics era has accelerated our understanding of how genetic and epigenetic factors influence both normal variable traits and disease risk in humans. However, the majority of "omics" studies have focused on individuals living in urban centers, primarily from Europe and Asia, neglecting much of the genetic and environmental variation that exists across worldwide populations. Comparative studies of gene regulation in ethnically diverse populations are informing our understanding of how evolutionary forces have shaped the genetic and molecular mechanisms underlying complex traits, and studying gene expression in different environmental contexts is enabling the dissection of disease-related pathways such as immune response. Such approaches are vital to the equitable application of genomics and medicine.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.