ArticleBrain and neuroscience advances2017
Segmenting subregions of the human hippocampus on structural magnetic resonance image scans: An illustrated tutorial.
Article in Brain and neuroscience advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In vivo quantitative imaging of hippocampal inflammation in autoimmune neuroinflammatory conditions: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Association Between Anterior Hippocampal Gyrification and Episodic Memory Performance in Neurotypical Young Adults.Hippocampus · 2026Article
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Functional MRI of the Human Hippocampus at 10.5T: Pushing the Boundaries of Spatial Resolution.bioRxiv : the preprint server for biology · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Representational differentiation and integration within the hippocampal circuit during naturalistic stimuli.Communications biology · 2026Article
- Microscale maps of bursting dynamics across human hippocampal slices from patients with epilepsy.Journal of neurophysiology · 2026Article
- Reorganisation of Cortico-Hippocampal White Matter Pathways in Healthy Ageing: Evidence for Paradoxical Shifts in Structural Connectivity.bioRxiv : the preprint server for biology · 2025Article
- Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II.bioRxiv : the preprint server for biology · 2025Article
- Disentangling structure-function relationships between the human hippocampus and the whole brain using track-weighted dynamic functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Subcortical brain volume variations in autistic individuals across the lifespan.Molecular autism · 2025Article
- Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory.Nature communications · 2025Article
- Pathological microcircuits and epileptiform events in patient hippocampal slices.bioRxiv : the preprint server for biology · 2025Article
- Pattern Separation and Pattern Completion Within the Hippocampal Circuit During Naturalistic Stimuli.Human brain mapping · 2025Article
- Automated parcellation and atlasing of the human subcortex with ultra-high resolution quantitative MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuroanatomy, episodic memory and inhibitory control of persian-kurdish simultaneous bilinguals.Scientific reports · 2024Article
- Article
- Attention-gated 3D CapsNet for robust hippocampal segmentation.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Hippocampal subfields and their neocortical interactions during autobiographical memory.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mapping mesoscale connectivity within the human hippocampus.NeuroImage · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
backgroundThe hippocampus plays a central role in cognition, and understanding the specific contributions of its subregions will likely be key to explaining its wide-ranging functions. However, delineating substructures within the human hippocampus in vivo from magnetic resonance image scans is fraught with difficulties. To our knowledge, the extant literature contains only brief descriptions of segmentation procedures used to delineate hippocampal subregions in magnetic resonance imaging/functional magnetic resonance imaging studies.
methodsConsequently, here we provide a clear, step-by-step and fully illustrated guide to segmenting hippocampal subregions along the entire length of the human hippocampus on 3T magnetic resonance images.
resultsWe give a detailed description of how to segment the hippocampus into the following six subregions: dentate gyrus/Cornu Ammonis 4, CA3/2, CA1, subiculum, pre/parasubiculum and the uncus. Importantly, this in-depth protocol incorporates the most recent cyto- and chemo-architectural evidence and includes a series of comprehensive figures which compare slices of histologically stained tissue with equivalent 3T images.
conclusionAs hippocampal subregion segmentation is an evolving field of research, we do not suggest this protocol is definitive or final. Rather, we present a fully explained and expedient method of manual segmentation which remains faithful to our current understanding of human hippocampal neuroanatomy. We hope that this 'tutorial'-style guide, which can be followed by experts and non-experts alike, will be a practical resource for clinical and research scientists with an interest in the human hippocampus.
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