Evidence map›Paper›PMID 28596958›Full record

ArticleFrontiers in cardiovascular medicine2017

Circulating Cellular Adhesion Molecules and Cognitive Function: The Coronary Artery Risk Development in Young Adults Study.

Cynthia Yursun Yoon, Lyn M Steffen, Myron D Gross, Lenore J Launer, Andrew Odegaard, Alexander Reiner, Otto Sanchez, Kristine Yaffe, Stephen Sidney, David R Jacobs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Inflammation, metabolic dysregulation and environmental neurotoxins and risk of cognitive decline and impairment in midlife.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Cynthia Yursun YoonDivision of Epidemiology and Community Heath, University of Minnesota, Minneapolis, MN, USA.
Lyn M SteffenDivision of Epidemiology and Community Heath, University of Minnesota, Minneapolis, MN, USA.
Myron D GrossDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
Andrew OdegaardDepartment of Epidemiology, University of California, Irvine, CA, USA.
Alexander ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Otto SanchezDivision of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, USA.
Kristine YaffeDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Stephen SidneyDivision of Research, Kaiser Permanente Oakland, Oakland, CA, USA.
David R JacobsDivision of Epidemiology and Community Heath, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USKaiser Permanente Oakland Medical Center · USNational Institute on Aging · USUniversity of California, Irvine · USUniversity of California, San Francisco · USUniversity of Washington · US

Funding

EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSISR01HL053560 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GROSS, MYRON D, JACOBS, DAVID R · 1995 to 2014
$9.0M
Brain aging and cardiovascular risk factors and diseaseZIAAG007480 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2011 to 2025
$2.7M
Cellular Adhesion Molecules: Genes, Phenotypes, and Coronary AtherosclerosisR01HL093077 · NHLBI · UNIVERSITY OF MINNESOTA · PI GROSS, MYRON D, REINER, ALEXANDER P · 2009 to 2010
$1.5M
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS R01 HL053560NHLBI NIH HHS R01 HL093077
6 · The paper itself

Abstract

objectiveHigher circulating concentrations of cellular adhesion molecules (CAMs) can be used as markers of endothelial dysfunction. Given that the brain is highly vascularized, we assessed whether endothelial function is associated with cognitive performance.

methodWithin the Coronary Artery Risk Development in Young Adults (CARDIA) Study, excluding

resultAll CAM concentrations were greater in year 15 vs. year 7. Adjusting for age, race, sex, education, smoking, alcohol, diet, physical activity, participants in the fourth vs. the first quartile of CARDIA year 7 of circulating intercellular adhesion molecule-1 (ICAM-1) scored worse on RAVLT, DSST, and Stroop Test (

conclusionHigher circulating ICAM-1 at average ages 32 and 40 was associated with lower cognitive skills at average age 50. The study is consistent with the hypothesis that endothelial dysfunction is associated with worse short-term memory, speed of processing, and executive function.

Indexed as

cellular adhesion moleculescognitive functionDigit Symbol Substitution Testintercellular adhesion molecule-1Rey Auditory Verbal Learning TestselectinStroop Testvascular cellular adhesion molecule-1

Identifiers

PMID28596958
PMCPMC5442165
OpenAlexW2618654485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.