Evidence map›Paper›PMID 28596833›Full record

ArticlePharmacology research & perspectives2017

Absorption, distribution, metabolism, and excretion of [

Yu-Luan Chen, Estela Skende, Jing Lin, Yijun Yi, Peter L Wang, Sarah Wills, H Scott Wilkinson, Kenneth S Koblan, Seth C Hopkins

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Absorption, distribution, metabolism, and excretion of [Pharmacology research & perspectives · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yu-Luan ChenSunovion Pharmaceuticals, Inc. Marlborough Massachusetts.
Estela SkendeSunovion Pharmaceuticals, Inc. Marlborough Massachusetts.
Jing LinSunovion Pharmaceuticals, Inc. Marlborough Massachusetts.
Yijun YiXenoBiotic Laboratories, Inc. Plainsboro New Jersey.
Peter L WangXenoBiotic Laboratories, Inc. Plainsboro New Jersey.
Sarah WillsCovance Laboratories, Inc. Madison Wisconsin.
H Scott WilkinsonSunovion Pharmaceuticals, Inc. Marlborough Massachusetts.
Kenneth S KoblanSunovion Pharmaceuticals, Inc. Marlborough Massachusetts.
Seth C HopkinsSunovion Pharmaceuticals, Inc. Marlborough Massachusetts.
Sunovion (United States) · USVion Pharmaceuticals (United States) · USCovance (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dasotraline is a dopamine and norepinephrine reuptake inhibitor, and the early clinical trials show a slow absorption and long elimination half-life. To investigate the absorption, distribution, metabolism, and excretion of dasotraline in humans, a single dose of [

Indexed as

Absorptiondasotralinedistributionexcretionglucuronidationmass spectrometrymetabolite identificationpharmacokineticsphase II metabolismsulfate conjugation

Identifiers

PMID28596833
PMCPMC5461651
OpenAlexW2567036611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.