ArticleEuropean surgery : ACA : Acta chirurgica Austriaca2017
Oxidative stress and angiogenesis in primary hyperparathyroidism.
Article in European surgery : ACA : Acta chirurgica Austriaca, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Meta-Analytical and Meta-Regression Evaluation of Subclinical Hyperthyroidism's Effect on Male Reproductive Health: Hormonal and Seminal Perspectives.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Article
- High prevalence of hyperuricemia and its risk factors in a Chinese cohort of primary hyperparathyroidism patients.Endocrine · 2025Article
- Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury.Acta cirurgica brasileira · 2024Article
- Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Effects of Qingshen Granules on the Oxidative Stress-NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region.European surgery : ACA : Acta chirurgica Austriaca · 2018Article
- Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications.Oxidative medicine and cellular longevity · 2018Article
- The Effect of Dexmedetomidine and Levobupivacaine in an Experimental Ischemia Reperfusion Model.In vivo (Athens, Greece)Article
- EFFECT OF PARATHYROIDECTOMY ON OXIDATIVE STRESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM.Acta endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe inappropriate elevation of parathormone (PTH), which regulates the process of angiogenesis in parathyroid tissue, causes the changes of activity of enzymes responsible for the removal of free radicals. Parathyroidectomy (PTX) in patients with primary hyperparathyroidism (PHPT) lowers the level of PTH and leads to the reduction of risk of cardiovascular and all-cause mortality by normalization of the antioxidant status. Therefore, the aims of the study were to assess the activity of antioxidant enzymes and free radical reaction products in patients after parathyroidectomy, and to evaluate the correlation between the systemic oxidative stress and angiogenic parameters. MATERIALS AND
methodsPatients with PHPT treated surgically were enrolled into the study. Total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), ceruloplasmin (CER), lipid hydroperoxides (LHP) and malondialdehyde (MDA) were measured before and after parathyroidectomy. The immunohistological expression of angiogenic factors in parathyroid specimens was assessed by the BrightVision method from ImmunoLogic using murine monoclonal anti-human: anti-VEGF, anti-CD31 and anti-CD106 antibodies.
resultsThe significant increase of TAC, CER, reduction of TOS, MDA, SOD, especially for cytoplasmic form, and significant decrease of OSI, LHP were observed after PTX. There was no significant correlation between changes of oxidative stress markers and angiogenic parameters: VEGF, CD-31, CD-106 in parathyroid tissue. The correlation level was low and medium.
conclusionsParathyroidectomy causes down-regulation of lipid peroxidation processes and leads to reduction of oxidative stress in patients with PHPT. The decrease in the OSI is the results of down-regulation of oxidative stress in the postoperative period. The change of the antioxidant status has no impact on angiogenesis processes in parathyroid tissue.
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