Evidence map›Paper›PMID 28596771›Full record

ReviewFrontiers in immunology2017

Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans.

Samuel J Hobbs, Jeffrey C Nolz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Aberrant Expression ofCancers · 2025
    Article
  4. Review
  5. Runx3 Regulates CD8International journal of molecular sciences · 2024
    Article
  6. Immunometabolism (Cobham, Surrey) · 2023
    Review
  7. T helper 1 effector memory CD4Cell reports · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Cosmc controls B cell homing.Nature communications · 2020
    Article
  17. GCNT1-MediatedJournal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  18. Review
  19. Control of memory CD8Molecular immunology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Samuel J HobbsDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, United States.
Jeffrey C NolzDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, United States.
Oregon Health & Science University · US

Funding

Program in Molecular and Cellular BiosciencesT32GM071338 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MASLEN, CHERYL L · 2005 to 2020
$3.5M
Regulation of Memory CD8 T cell Trafficking to Inflamed TissuesK22AI102981 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI NOLZ, JEFFREY C. · 2014 to 2015
$270k
NIAID NIH HHS K22 AI102981NIGMS NIH HHS T32 GM071338
6 · The paper itself

Abstract

Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes. In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to initiate extravasation into non-lymphoid tissues. The capacity for T cells to interact with all of these selectins is dependent on the enzymatic synthesis of complex O-glycans, and thus, this protein modification plays an indispensable role in regulating the distribution and homing of both naive and previously activated T cells

Indexed as

high endothelial venulesinflammationO-glycansPSGL-1selectinssialyl Lewis XT cell memoryT cell trafficking

Identifiers

PMID28596771
PMCPMC5442166
OpenAlexW2618985326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.