Evidence map›Paper›PMID 28596683›Full record

ArticleWorld journal of gastroenterology2017

Polymorphisms of microRNA target genes

Vytenis Petkevicius, Violeta Salteniene, Simonas Juzenas, Thomas Wex, Alexander Link, Marcis Leja, Ruta Steponaitiene, Jurgita Skieceviciene, Limas Kupcinskas, Laimas Jonaitis and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. MicroRNAs in Genetic Etiology of Human Diseases.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  7. Downregulating circRNA_0044516 Inhibits Cell Proliferation in Gastric Cancer Through miR-149/Wnt1/β-catenin Pathway.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
  8. Molecular Alterations in Gastric Intestinal Metaplasia.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Gastritis Stages in Monozygotic and Dizygotic Dyspeptic Twins.Gastroenterology research and practice · 2020
    Article
  14. Article
  15. Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST.International journal of molecular sciences · 2018
    Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Vytenis PetkeviciusVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Violeta SaltenieneVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Simonas JuzenasVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Thomas WexVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Alexander LinkVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Marcis LejaVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Ruta SteponaitieneVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Jurgita SkiecevicieneVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Limas KupcinskasVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Laimas JonaitisVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Gediminas KiudelisVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Peter MalfertheinerVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
Juozas KupcinskasVytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania.
University of Latvia · LVLithuanian University of Health Sciences · LTOtto-von-Guericke University Magdeburg · DERiga East University Hospital · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate associations between miRNA target genes

methodsGene polymorphisms were analyzed in 508 controls and 474 GC patients from 3 tertiary centers in Germany, Lithuania and Latvia. Controls were patients from the out-patient departments, who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy. Gastric cancer (GC) patients had histopathological verification of gastric adenocarcinoma. Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.

resultsWe observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of

conclusion

Indexed as

Polymorphism, Single NucleotideAdultAgedAntigens, CDCase-Control StudiesCyclin D1FemaleGenotypeGermanyHumansInterleukin-10Interleukin-12 Subunit p40LatviaLeukocytes, MononuclearLithuaniaMaleAntigens, CDCCND1 protein, humanCyclin D1IL10 protein, humanIL12B protein, humanINSR protein, humanInterleukin-10Interleukin-12 Subunit p40Receptor, InsulinGastric cancermiRNASingle-nucleotide polymorphismsTarget genes

Identifiers

PMID28596683
PMCPMC5442083
OpenAlexW2616528001

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.